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Product overview

  • Name
    ZD 7288
  • Short description
    HCN channel blocker. Modulates sino-atrial node function.
  • Biological description

    Hyperpolarization-activated, cyclic nucleotide-gated cation (HCN) channel blocker (IC50 = 15.0 µM).

    Modulates sino-atrial node function; blocks the hyperpolarization-activated inward current If and inhibits Ih in central neurons.

    Also inhibits Na+ currents in dorsal root ganglion neurons (IC50 = 1.17 µM).

    Blocks long term potentiation (LTP) induction and displays anxiolytic properties.

    Also increases doubling time of embryonic stem cells (ESCs) and modulates differentiation outcomes. Active in vivo.

  • Biological action
  • Purity
  • Citations


  • Chemical name
    4-Ethylphenylamino-1,2-dimethyl-6-methylaminopyrimidinium chloride
  • Molecular Weight
  • Chemical structure
    ZD 7288  [133059-99-1]
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • Source
  • InChi
  • InChiKey
  • MDL number
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    +4°C (desiccate)
  • Solubility overview
    Soluble in water (100mM) or DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for ZD 7288

  • Is ZD7288 a selective blocker of hyperpolarization-activated cyclic nucleotide-gated channel currents?

    Wu X et al (2012) Channels (Austin) 6(6) : 438-42.
    PubMedID: 22989944
  • Intrahippocampal infusion of the Ih blocker ZD7288 slows evoked theta rhythm and produces anxiolytic-like effects in the elevated plus maze.

    Yeung M et al (2013) Hippocampus 23(4) : 278-86.
    PubMedID: 23280856
  • Inhibitory actions of ZENECA ZD7288 on whole-cell hyperpolarization activated inward current (If) in guinea-pig dissociated sinoatrial node cells.

    BoSmith RE et al (1993) Br J Pharmacol 110(1) : 343-9.
    PubMedID: 7693281
  • ZD7288, a blocker of the HCN channel family, increases doubling time of mouse embryonic stem cells and modulates differentiation outcomes in a context-dependent manner.

    Omelyanenko et al (2016) Springerplus 16 : 5:41
    PubMedID: 26835223
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