Product overview

  • Name
    ZD 7288
  • Short description
    HCN channel blocker. Modulates sino-atrial node function.
  • Biological description

    Hyperpolarization-activated, cyclic nucleotide-gated cation (HCN) channel blocker (IC50 = 15.0 µM).

    Modulates sino-atrial node function; blocks the hyperpolarization-activated inward current If and inhibits Ih in central neurons.

    Also inhibits Na+ currents in dorsal root ganglion neurons (IC50 = 1.17 µM).

    Blocks long term potentiation (LTP) induction and displays anxiolytic properties.

    Also increases doubling time of embryonic stem cells (ESCs) and modulates differentiation outcomes. Active in vivo.

  • Biological action
    Blocker
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    4-Ethylphenylamino-1,2-dimethyl-6-methylaminopyrimidinium chloride
  • Molecular Weight
    292.81
  • Chemical structure
    ZD 7288  [133059-99-1]
  • Molecular Formula
    C15H21ClN4
  • CAS Number
    133059-99-1
  • PubChem identifier
    123983
  • SMILES
    CCN(C1=CC=CC=C1)C2=CC(=NC)N(C(=N2)C)C.Cl
  • Source
    Synthetic
  • InChi
    InChI=1S/C15H20N4.ClH/c1-5-19(13-9-7-6-8-10-13)15-11-14(16-3)18(4)12(2)17-15;/h6-11H,5H2,1-4H3;1H
  • InChiKey
    DUWKUHWHTPRMAP-UHFFFAOYSA-N
  • MDL number
    MFCD16879001
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    +4°C (desiccate)
  • Solubility overview
    Soluble in water (100mM) or DMSO (100mM)

References for ZD 7288

  • Is ZD7288 a selective blocker of hyperpolarization-activated cyclic nucleotide-gated channel currents?

    Wu X et al (2012) Channels (Austin) 6(6) : 438-42.
    PubMedID: 22989944
  • Contribution of Ih to the relative facilitation of synaptic responses induced by carbachol in the entorhinal cortex during repetitive stimulation of the parasubiculum.

    Sparks DW et al (2014) Neuroscience 278 : 81-92.
    PubMedID: 25130557
  • Intrahippocampal infusion of the Ih blocker ZD7288 slows evoked theta rhythm and produces anxiolytic-like effects in the elevated plus maze.

    Yeung M et al (2013) Hippocampus 23(4) : 278-86.
    PubMedID: 23280856
  • Inhibitory actions of ZENECA ZD7288 on whole-cell hyperpolarization activated inward current (If) in guinea-pig dissociated sinoatrial node cells.

    BoSmith RE et al (1993) Br J Pharmacol 110(1) : 343-9.
    PubMedID: 7693281
  • ZD7288, a blocker of the HCN channel family, increases doubling time of mouse embryonic stem cells and modulates differentiation outcomes in a context-dependent manner.

    Omelyanenko et al (2016) Springerplus 16 : 5:41
    PubMedID: 26835223