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Zebularine

(HB1378)
Data

Product overview

  • Name
    Zebularine
  • Short description
    DNA methyltransferase inhibitor. Induces cardiomyocyte differentiation in MSCs.
  • Biological description
    DNA methyltransferase inhibitor. Stabilises p53 in colorectal cancer cells and causes p53-dependent ER stress and autophagy. Also inhibits cytidine deaminase and influences embryonic stem cell differentiation. Shows anti-proliferative and anti-cancer actions.
  • Alternative names
    1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one; 2-Pyrimidone-1-β-D-riboside; NSC 309132; Zeb
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    1-β-D-Ribofuranosyl-2(1H)-pyrimidino ne
  • Molecular Weight
    228.2
  • Chemical structure
    Zebularine  [654065]
  • Molecular Formula
    C9H12N2O5
  • CAS Number
    654065

Storing and Using Your Product

  • Storage instructions
    room temperature (desiccate)
  • Solubility overview
    soluble in water (100mM) or DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Zebularine

  • Zebularine inhibits tumorigenesis and stemness of colorectal cancer via p53-dependent endoplasmic reticulum stress.

    Yang PM et al (2013) Sci Rep 3 : 3219
    PubMedID: 24225777
  • Zebularine regulates early stages of mESC differentiation: effect on cardiac commitment.

    Horrillo A et al (2013) Cell Death Dis 4 : e570.
    PubMedID: 23559004
  • Potent inhibitors for the deamination of cytosine arabinoside and 5-aza-2'-deoxycytidine by human cytidine deaminase.

    Lalibertã? J et al (1992) Cancer Chemother Pharmacol 30(1) : 7-11.
    PubMedID: 1375134
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