ZM 447439

(HB1444)

Product overview

  • Name
    ZM 447439
  • Short description
    Potent, selective, ATP-competitive Aurora kinase B inhibitor
  • Biological description
    Potent, selective and ATP-competitive Aurora kinase B inhibitor (IC50 values are 50, 250 and 1000 nM for Aurora kinase B, C and A respectively). Inhibits mitotic chromosome alignment, mitotic segregation and cytokinesis. Shows anti-proliferative and anti-cancer actions.
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    N-[4-[[6-Methoxy-7-[3-(4-morpholiny l)propoxy]-4-quinazolinyl]amino]phenyl]benzamide
  • Molecular Weight
    513.59
  • Chemical structure
    ZM 447439  [331771-20-1]
  • Molecular Formula
    C29H31N5O4
  • CAS Number
    331771-20-1

Storing and Using Your Product

  • Storage instructions
    room temperature (desiccate)
  • Solubility overview
    soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for ZM 447439

  • Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores.

    Ditchfield C et al (2003) J Cell Biol 161(2) : 267-80.
    PubMedID: 12719470
  • Validating Aurora B as an anti-cancer drug target.

    Girdler F et al (2006) J Cell Sci 119(Pt 17) : 3664-75.
    PubMedID: 16912073
  • ZM447439, the Aurora kinase B inhibitor, suppresses the growth of cervical cancer SiHa cells and enhances the chemosensitivity to cisplatin.

    Zhang L et al (2011) J Obstet Gynaecol Res 37(6) : 591-600.
    PubMedID: 21159048

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