Zoniporide dihydrochloride

(HB1137)

Product overview

  • Name
    Zoniporide dihydrochloride
  • Short description
    Potent, selective Na+ / H+ exchanger-1 inhibitor
  • Biological description
    Potent and selective Na+/H+ exchanger-1 (NHE-1) inhibitor (IC50 = 14 nM). Exhibits 157- fold and 15,700- fold selectivity for NHE1 over human NHE-2 and rat NHE-3 respectively. Displays cardioprotective properties and reduces both the incidence and duration of ischemia-reperfusion.
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    [1-(Quinolin-5-yl)-5-cyclopropyl-1H -pyrazole-4-carbonyl]guanidine dihydrochloride
  • Molecular Weight
    393.27
  • Chemical structure
    Zoniporide dihydrochloride  [241799-10-0]
  • Molecular Formula
    C17H16N6O.2HCl
  • CAS Number
    241799-10-0

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    soluble in water (10mM) or DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Zoniporide dihydrochloride

  • Zoniporide: a potent and highly selective inhibitor of human Na(+)/H(+) exchanger-1.

    Marala RB et al (2002) Eur J Pharmacol 451(1) : 37-41.
    PubMedID: 12223226
  • [Cardioprotective properties of zoniporide studied on experimental ischemia and reperfusion models in rat myocardium].

    Gurova NA et al (2013) Eksp Klin Farmakol 76(8) : 17-9.
    PubMedID: 24228483
  • Zoniporide: a potent and selective inhibitor of the human sodium-hydrogen exchanger isoform 1 (NHE-1).

    Tracey WR et al (2003) Cardiovasc Drug Rev 21(1) : 17-32.
    PubMedID: 12595915

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