Zonisamide

(HB0675)

Product overview

  • Name
    Zonisamide
  • Short description
    Non-selective Na+ / Ca2+ channel blocker
  • Biological description
    Non-selective voltage-dependent Na+ and T-type Ca2+ channel blocker. Enhances BK(Ca) channels by increasing the time they are open. Scavenges free radicals and influences monoamine, glutamate and GABA neurotransmission. Acts as an anti-epileptic and shows neuroprotective and some anti-Parkinsonian actions.
  • Biological action
    Blocker
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    1,2-Benzisoxazole-3-methanesulfonamide
  • Molecular Weight
    212.22
  • Chemical structure
    Zonisamide  [68291-97-4]
  • Molecular Formula
    C8H8N2O3S
  • CAS Number
    68291-97-4

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in water (10mM) or DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Zonisamide

  • Zonisamide: a new antiepileptic drug.

    Sobieszek G et al (2003) Pol J Pharmacol 55(5) : 683-9.
    PubMedID: 14704463
  • Activation by zonisamide, a newer antiepileptic drug, of large-conductance calcium-activated potassium channel in differentiated hippocampal neuron-derived H19-7 cells.

    Huang CW et al (2007) J Pharmacol Exp Ther 321(1) : 98-106.
    PubMedID: 17255467
  • Zonisamide attenuates α-synuclein neurotoxicity by an aggregation-independent mechanism in a rat model of familial Parkinson's disease.

    Arawaka S et al (2014) PLoS One 9(2) : e89076.
    PubMedID: 24586512

Reviews & Product Guides