Zonisamide

(HB0675)

(HB0675)

Data

Product overview

Name
Zonisamide
Short description
Non-selective Na⁺ / Ca²⁺ channel blocker
Biological description
Non-selective voltage-dependent Na⁺ and T-type Ca²⁺ channel blocker. Enhances BK(Ca) channels by increasing the time they are open. Scavenges free radicals and influences monoamine, glutamate and GABA neurotransmission. Acts as an anti-epileptic and shows neuroprotective and some anti-Parkinsonian actions.
Biological action
Blocker
Purity
>99%
Citations
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Storage instructions
+4°C
Solubility overview
soluble in water (10mM) or DMSO (100mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Zonisamide: a new antiepileptic drug.
Sobieszek G et al (2003) Pol J Pharmacol 55(5) : 683-9.
PubMedID: 14704463
Activation by zonisamide, a newer antiepileptic drug, of large-conductance calcium-activated potassium channel in differentiated hippocampal neuron-derived H19-7 cells.
Huang CW et al (2007) J Pharmacol Exp Ther 321(1) : 98-106.
PubMedID: 17255467
Zonisamide attenuates α-synuclein neurotoxicity by an aggregation-independent mechanism in a rat model of familial Parkinson's disease.
Arawaka S et al (2014) PLoS One 9(2) : e89076.
PubMedID: 24586512

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