Zonisamide
(HB0675)- Data
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Data
Product overview
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NameZonisamide
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Short descriptionNon-selective Na+ / Ca2+ channel blocker
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Biological descriptionNon-selective voltage-dependent Na+ and T-type Ca2+ channel blocker. Enhances BK(Ca) channels by increasing the time they are open. Scavenges free radicals and influences monoamine, glutamate and GABA neurotransmission. Acts as an anti-epileptic and shows neuroprotective and some anti-Parkinsonian actions.
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Biological actionBlocker
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Purity>99%
- Citations
Properties
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Chemical name1,2-Benzisoxazole-3-methanesulfonamide
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Molecular Weight212.22
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Chemical structure
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Molecular FormulaC8H8N2O3S
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CAS Number68291-97-4
Storing and Using Your Product
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Storage instructions+4°C
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Solubility overviewsoluble in water (10mM) or DMSO (100mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Zonisamide
Zonisamide: a new antiepileptic drug.
Sobieszek G et al (2003) Pol J Pharmacol 55(5) : 683-9.PubMedID: 14704463Activation by zonisamide, a newer antiepileptic drug, of large-conductance calcium-activated potassium channel in differentiated hippocampal neuron-derived H19-7 cells.
Huang CW et al (2007) J Pharmacol Exp Ther 321(1) : 98-106.PubMedID: 17255467Zonisamide attenuates α-synuclein neurotoxicity by an aggregation-independent mechanism in a rat model of familial Parkinson's disease.
Arawaka S et al (2014) PLoS One 9(2) : e89076.PubMedID: 24586512
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