Product overview

  • Name
    Z-VAD-FMK
  • Short description
    Broad spectrum caspase inhibitor
  • Biological description
    Broad spectrum caspase inhibitor. Blocks apoptosis and activation of caspases during Fas-L induced apoptosis. Also Inhibits T-cell proliferation displaying immunosuppressive properties.
  • Alternative names
    ZVAD-FMK; Z-VAD.FMK
  • Biological action
    Inhibitor
  • Our products in action

Properties

  • Chemical name
    Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone
  • Molecular Weight
    467.49
  • Chemical structure
    Z-VAD-FMK  [187389-52-2]
  • Molecular Formula
    C22H30FN3O7
  • CAS Number
    187389-52-2
  • PubChem identifier
    5497174
  • SMILES
    C[C@@H](C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)[C@H](C(C)C)NC(=O)OCC1=CC=CC=C1
  • InChi
    InChI=1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)/t14-,16-,19-/m0/s1
  • InChiKey
    MIFGOLAMNLSLGH-QOKNQOGYSA-N
  • MDL number
    MFCD01074990

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    Soluble in DMSO (20 mM)

References for Z-VAD-FMK

  • Radiation-induced cytochrome c release and the neuroprotective effects of the pan-caspase inhibitor z-VAD-fmk in the hypoglossal nucleus.

    Li J et al (2014) Exp Ther Med 7(2) : 383-388.
    PubMedID: 24396410
  • Suppression of human T cell proliferation by the caspase inhibitors, z-VAD-FMK and z-IETD-FMK is independent of their caspase inhibition properties.

    Lawrence CP et al (2012) Toxicol Appl Pharmacol 265(1) : 103-12.
    PubMedID: 22982538
  • Inhibition of human caspases by peptide-based and macromolecular inhibitors.

    Garcia-Calvo M et al (1998) J Biol Chem 273(49) : 32608-13.
    PubMedID: 9829999
  • Correlation of tumor necrosis factor alpha (TNF alpha) with high Caspase 3-like activity in myelodysplastic syndromes.

    Mundle SD et al (1999) Cancer Lett 140(1-2) : 201-7.
    PubMedID: 10403560

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