Product overview

Name Z-VAD-FMK
Alternative names ZVAD-FMK; Z-VAD.FMK
Description Broad spectrum caspase inhibitor
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Biological Data

Biological description Broad spectrum caspase inhibitor. Blocks apoptosis and activation of caspases during Fas-L induced apoptosis. Also Inhibits T-cell proliferation displaying immunosuppressive properties.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (20 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone
Molecular Weight 467.49
Chemical structure Z-VAD-FMK  [187389-52-2] Chemical Structure
Molecular Formula C22H30FN3O7
CAS Number 187389-52-2
PubChem identifier 5497174
SMILES C[C@@H](C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)[C@H](C(C)C)NC(=O)OCC1=CC=CC=C1
InChi InChI=1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)/t14-,16-,19-/m0/s1
InChiKey MIFGOLAMNLSLGH-QOKNQOGYSA-N
MDL number MFCD01074990

References for Z-VAD-FMK

References are publications that support the biological activity of the product
  • Radiation-induced cytochrome <i>c</i> release and the neuroprotective effects of the pan-caspase inhibitor z-VAD-fmk in the hypoglossal nucleus.

    Li J et al (2014) Exp Ther Med 7(2) : 383-388.
  • Suppression of human T cell proliferation by the caspase inhibitors, z-VAD-FMK and z-IETD-FMK is independent of their caspase inhibition properties.

    Lawrence CP et al (2012) Toxicol Appl Pharmacol 265(1) : 103-12.
  • Correlation of tumor necrosis factor alpha (TNF alpha) with high Caspase 3-like activity in myelodysplastic syndromes.

    Mundle SD et al (1999) Cancer Lett 140(1-2) : 201-7.
  • Inhibition of human caspases by peptide-based and macromolecular inhibitors.

    Garcia-Calvo M et al (1998) J Biol Chem 273(49) : 32608-13.

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