Z-VAD-(OMe)-FMK

(HB1319)

Product overview

  • Name
    Z-VAD-(OMe)-FMK
  • Short description
    Irreversible, cell permeable, broad spectrum caspase inhibitor.
  • Biological description
    Irreversible, cell permeable, broad spectrum caspase inhibitor. Also inhibits PARP-1 cleavage and Fas-induced apoptosis. Hydrolysed by endogenous esterases into the biologically active form Z-VAD-FMK.
  • Biological action
    Inhibitor
  • Purity
    >95%
  • Citations

Properties

  • Chemical name
    Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone
  • Molecular Weight
    467.48
  • Chemical structure
    Z-VAD-(OMe)-FMK  [187389-52-2]
  • Molecular Formula

    C22H30FN3O7

  • CAS Number
    187389-52-2
  • PubChem identifier
    5497174
  • SMILES
    C[C@@H](C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)[C@H](C(C)C)NC(=O)OCC1=CC=CC=C1
  • InChi
    InChI=1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)/t14-,16-,19-/m0/s1
  • InChiKey
    MIFGOLAMNLSLGH-QOKNQOGYSA-N
  • MDL number
    MFCD01074990
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Z-VAD-(OMe)-FMK

  • Amyloid precursor protein binding protein Fe65 is cleaved by caspases during DNA damage-induced apoptosis.

    Saeki K et al (2011) Biol Pharm Bull 34(2) : 290-4.
    PubMedID: 21415543
  • Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32.

    Slee EA et al (1996) Biochem J 315 ( Pt 1) : 21-4.
    PubMedID: 8670109
  • A specific inhibitor of apoptosis decreases tissue injury after intestinal ischemia-reperfusion in mice.

    Farber A et al (1999) J Vasc Surg 30(4) : 752-60.
    PubMedID: 10514215

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