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Perlapine hydrochloride - an exclusive new DREADD ligand

Perlapine hydrochloride  - an exclusive new DREADD ligand
By Sam Roome 8 months ago 21456 Views No comments

Here is another exclusive from Hello Bio! Perlapine hydrochloride is a water soluble version of perlapine which is a novel, potent and selective, non-CNO (Clozapine N Oxide) hM3Dq DREADD receptor agonist (EC50 = 2.8 nM). It shows >10,000-fold selectivity for hM3Dq over hM3 muscarinic receptors. Perlapine also activates the inhibitory hM2Di and hM4Di Gi-DREADDs. Unlike CNO, perlapine is especially suited for translational studies. Perlapine also acts as a sleep inducing, hypnotic agent. Find out more