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CNQX disodium salt


Product overview

  • Name
    CNQX disodium salt
  • Short description
    Potent, competitive AMPA / kainate receptor antagonist. Disodium salt.
  • Biological description

    CNQX disodium salt is a water soluble, potent and competitive AMPA and kainate receptor antagonist. CNQX also antagonizes NMDA receptors at the glycine site.

    CNQX increases GABAA receptor spontaneous postsynaptic currents (sPSCs) and also shows neuroprotective actions.

    CNQX also available.

  • Biological action
  • Purity
  • Customer comments

    The CNQX is going fine ! Verified customer, IBPS, Inserm, CNRS

    It works exactly as it should! Dissolved in water, kept in aliquots in -20 freezer. Verified customers, SickKids (University of Toronto)

  • Citations



  • Chemical name
    6-Cyano-7-nitroquinoxaline-2,3-dione disodium
  • Molecular Weight
  • Chemical structure
    CNQX disodium salt  [479347-85-8]
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • Source
  • InChi
  • InChiKey
  • MDL number
  • Appearance
    Brown or yellow solid


  • Application notes

    The AMPA receptor antagonist CNQX disodium salt is commonly used at concentrations of 10 μM to inhibit the actions of glutamate acting on AMPARs.

    CNQX disodium salt from Hello Bio reduces both spontaneous and evoked EPSCs in cortical neurons at concentrations of 1 μM with full AMPA receptor blockade at 10 μM (see Fig 1 above).


    #Protocol 1: Evoked and spontaneous excitatory post synaptic currents (EPSCs)

    • Whole cell voltage clamp recordings were obtained from layer V neurons of the mouse prelimbic cortex brain slice.
    •  EPSCs were evoked via a stimulating electrode placed in layers II/III delivering a single square (150 μs) pulse every 10 sec at an intensity that gave a reliable EPSC.
    • Neurons were held at -70 to -60 mV (the reversal potential of GABA currents). EPSCs were continuously stimulated and recorded in response to 5 min applications of varying concentrations of CNQX disodium salt until complete receptor inhibition.
    • Spontaneous EPSCs were recorded before and after addition of CNQX disodium salt by holding the neuron at -70 mV and recording for 10 sec.
    • Recordings for EPSCs were made in the absence of GABAA-R antagonists.

Storing and Using Your Product

  • Storage instructions
    Room temperature (desiccate)
  • Solubility overview
    Soluble in water (20mM)
  • Handling
    Hydroscopic solid, contact with air may cause material to change colour and become sticky. Product performance should not be affected but we recommend storing the material in a sealed jar.
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for CNQX disodium salt

  • 6,7-Dinitro-quinoxaline-2,3-dion and 6-nitro,7-cyano-quinoxaline-2,3-dion antagonise responses to NMDA in the rat spinal cord via an action at the strychnine-insensitive glycine receptor.

    Birch PJ et al (1988) Eur J Pharmacol 156(1) : 177-80.
    PubMedID: 2905271
  • The calpain inhibitor MDL-28170 and the AMPA/KA receptor antagonist CNQX inhibit neurofilament degradation and enhance neuronal survival in kainic acid-treated hippocampal slice cultures.

    Lopez-Picon FR et al (2006) Eur J Neurosci 23(10) : 2686-94.
    PubMedID: 16817871
  • 6-Cyano-7-nitroquinoxaline-2,3-dione (CNQX) increases GABAA receptor-mediated spontaneous postsynaptic currents in the dentate granule cells of rat hippocampal slices.

    Hashimoto Y et al (2004) Neurosci Lett 358(1) : 33-6.
    PubMedID: 15016428
  • Pharmacological characterization of glutamatergic agonists and antagonists at recombinant human homomeric and heteromeric kainate receptors in vitro.

    Alt et al (2004) Neuropharmacology 46(6) : 793-806
    PubMedID: 15033339
Our products in action
The following papers have cited the use of CNQX disodium salt (HB0205) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • Early life stress impairs postnatal oligodendrogenesis and adult behavior through activity-dependent mechanisms

    Teissier et al(2018) bioRxiv : 10.1101/369660
  • Tetrabromobisphenol A-induced depolarization of rat cerebellar granule cells: ex vivo and in vitro studies.

    Diamandakis et al(2019) Chemosphere 223 : 67-73
    PubMedID: 30769291
Support & Resources


  • Verified customer

    It does what it should. The CNQX works exactly as expected and at a considerable cost savings.
  • Verified customer

    It works well. I used to purchase CNQX/NBQX from Tocris and it was the first time to purchase CNQX from Hello Bio since it was cheaper than the one from Tocris. There was no issue to dissolve the CNQX disodium salt with water and it blocked EPSCs as it is supposed to be. I am pretty happy with product and will definitely consider trying other products.
  • Verified customer

    We mostly like the price – we use a lot in our experiments, so price is really important for us. All compounds we purchased so far from you worked really well – no surprises. So we are very happy we found you – because with your compounds we can significantly cut the cost of our experiments.
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