CP 465022 hydrochloride

(HB0214)

Product overview

  • Name
    CP 465022 hydrochloride
  • Short description
    Potent, non-competitive AMPA receptor antagonist
  • Biological description

    Potent and non-competitive AMPA receptor antagonist (IC50 = 25 nM). Weakly inhibits NMDA, GABA and kainate receptors. Displays anticonvulsant actions.


    This product is a mixture of the active isomer CP 465022 and the inactive isomer CP 465021. The mixture itself is also known as CP 392110.

    Please note that there is confusion in the life science marketplace and scientific literature regarding the correct naming of this product and typically, where the product is cited as CP465022, it is generally the mixture of both isomers that is being referred to. If you need any further clarification, please contact customercare@hellobio.com

  • Alternative names
    CP 392110
  • Biological action
    Antagonist
  • Purity
    >99%
  • Customer comments

    Good price, fast delivery Verified customer, University of Copenhagen

  • Our products in action

Properties

  • Chemical name
    3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H) -quinazolinone hydrochloride
  • Molecular Weight
    499.41
  • Chemical structure
    CP 465022 hydrochloride  [199655-36-2]
  • Molecular Formula
    C26H24ClFN4O.HCl
  • CAS Number
    199655-36-2
  • PubChem identifier
    67241566
  • SMILES
    CCN(CC)CC1=CC=CC(=N1)C=CC2=NC3=C(C=C(C=C3)F)C(=O)N2C4=CC=CC=C4Cl.Cl
  • InChi
    InChI=1S/C26H24ClFN4O.ClH/c1-3-31(4-2)17-20-9-7-8-19(29-20)13-15-25-30-23-14-12-18(28)16-21(23)26(33)32(25)24-11-6-5-10-22(24)27;/h5-16H,3-4,17H2,1-2H3;1H
  • InChiKey
    YKYDGCRJPYLXHY-UHFFFAOYSA-N

Storing and Using Your Product

  • Storage instructions
    Room temperature (desiccate)
  • Solubility overview
    Soluble in water (10mM) and in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for CP 465022 hydrochloride

  • Characterization of the binding site for a novel class of noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonists.

    Menniti FS et al (2000) Mol Pharmacol 58(6) : 1310-7.
    PubMedID: 11093768
  • CP-465,022, a selective noncompetitive AMPA receptor antagonist, blocks AMPA receptors but is not neuroprotective in vivo.

    Menniti FS et al (2003) Stroke 34(1) : 171-6.
    PubMedID: 12511770
  • Functional characterization of CP-465,022, a selective, noncompetitive AMPA receptor antagonist.

    Lazzaro JT et al (2002) Neuropharmacology 42(2) : 143-53.
    PubMedID: 11804610

Reviews

  • Verified customer, University of Copenhagen

    Good price, fast delivery