Product overview

  • Name
    D-Serine
  • Short description
    NMDA receptor co-agonist
  • Biological description
    Endogenous NMDA receptor co-agonist. Binds at the glycine site with higher potency than glycine. Induces Ca2+-dependent inactivation of GluN2A subunit-containing NMDA receptors with potential neuroprotective effects.
  • Biological action
    Agonist
  • Our products in action

Properties

  • Chemical name
    (R)-2-amino-3-hydroxypropanoic acid
  • Molecular Weight
    105.09
  • Chemical structure
    D-Serine  [312-84-5]
  • Molecular Formula
    C3H7NO3
  • CAS Number
    312-84-5
  • PubChem identifier
    71077
  • SMILES
    C([C@H](C(=O)O)N)O
  • InChi
    InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
  • InChiKey
    MTCFGRXMJLQNBG-UWTATZPHSA-N
  • MDL number
    MFCD00004269

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in water (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for D-Serine

  • D-amino acids in the brain: D-serine in neurotransmission and neurodegeneration.

    Wolosker H et al (2008) FEBS J 275(14) : 3514-26.
    PubMedID: 18564180
  • D-Serine-induced Inactivation of NMDA Receptors in Cultured Rat Hippocampal Neurons Expressing NR2A Subunits is Ca(2+) -Dependent.

    Li X et al (2014) CNS Neurosci Ther 20(11) : 951-60.
    PubMedID: 25042179
  • Long-term potentiation depends on release of D-serine from astrocytes.

    Henneberger C et al (2010) Nature 463(7278) : 232-6.
    PubMedID: 20075918