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JF-NP-26 (Caged-Raseglurant)


Product overview

  • Name
    JF-NP-26 (Caged-Raseglurant)
  • Short description
    Novel, inactive photocaged derivative of raseglurant which can be uncaged with violet light. Shows light-dependent analgesic activity in vivo.
  • Biological description

    JF-NP-26 (Caged-Raseglurant) is a novel, inactive photocaged derivative of raseglurant/ADX-10059 (the mGlu5 receptor negative allosteric modulator (NAM)).

    JF-NP-26 (Caged-Raseglurant) can be illuminated and uncaged by violet light (405 nM), to release raseglurant with spatial and temporal precision and allow local modulation of mGlu5 receptors. Unlike other caged compounds, JF-NP-26 can be uncaged by light within the visible spectrum which is advantageous for translation studies.

    JF-NP-26 (Caged-Raseglurant) is active in vivo, can be administered systemically and activated by LED-based illumination to induce JF-NP-26-mediated, light-dependent analgesia in both neuropathic and acute/tonic inflammatory pain models. No liver toxicity was observed in JF-NP-26 treatments used in tested pain models.

  • Biological action
  • Purity
  • Citations


  • Chemical name
    (7-(diethylamino)-2-oxo-2H-chromen-4-yl)methyl (2-((3-fluorophenyl)ethynyl)-4,6-dimethylpyidin-3-yl)carbamate
  • Molecular Weight
  • Chemical structure
  • Molecular Formula
  • Source
  • InChiKey
  • Appearance
    Yellow solid

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    Soluble in DMSO (100mM)
  • Handling
    This compound is light sensitive; exposure to light may affect compound performance. We therefore recommend storing the material in the dark and protecting from light.
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

References for JF-NP-26 (Caged-Raseglurant)

  • Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator.

    Font et al (2017) ELife pii: e23545. : doi: 10.7554/eLife.23545.
    PubMedID: 28395733
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