JF-NP-26 (Caged-Raseglurant)

(HB6127)

Product overview

  • Name
    JF-NP-26 (Caged-Raseglurant)
  • Short description
    Novel, inactive photocaged derivative of raseglurant which can be uncaged with violet light. Shows light-dependent analgesic activity in vivo.
  • Biological description

    JF-NP-26 (Caged-Raseglurant) is a novel, inactive photocaged derivative of raseglurant (the mGlu5 receptor negative allosteric modulator (NAM)).


    JF-NP-26 (Caged-Raseglurant) can be illuminated and uncaged by violet light (405 nM), to release raseglurant with spatial and temporal precision and allow local modulation of mGlu5 receptors. Unlike other caged compounds, JF-NP-26 can be uncaged by light within the visible spectrum which is advantageous for translation studies.


    JF-NP-26 (Caged-Raseglurant) is active in vivo, can be administered systemically and activated by LED-based illumination to induce JF-NP-26-mediated, light-dependent analgesia in both neuropathic and acute/tonic inflammatory pain models. No liver toxicity was observed in JF-NP-26 treatments used in tested pain models.

  • Biological action
    NAM
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    (7-(diethylamino)-2-oxo-2H-chromen-4-yl)methyl (2-((3-fluorophenyl)ethynyl)-4,6-dimethylpyidin-3-yl)carbamate
  • Molecular Weight
    513.57
  • Chemical structure
    JF-NP-26
  • Molecular Formula
    C30H28FN3O4
  • Source
    Synthetic
  • InChiKey
    XBUISHYVUXKBCO-UHFFFAOYSA-N
  • Appearance
    Yellow solid

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    Soluble in DMSO (100mM)
  • Handling
    This compound is light sensitive; exposure to light may affect compound performance. We therefore recommend storing the material in the dark and protecting from light.
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

References for JF-NP-26 (Caged-Raseglurant)

  • Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator.

    Font et al (2017) ELife pii: e23545. : doi: 10.7554/eLife.23545.
    PubMedID: 28395733