Novel, inactive photocaged derivative of raseglurant which can be uncaged with violet light. Shows light-dependent analgesic activity in vivo.
JF-NP-26 (Caged-Raseglurant) is a novel, inactive photocaged derivative of raseglurant/ADX-10059 (the mGlu5 receptor negative allosteric modulator (NAM)).
JF-NP-26 (Caged-Raseglurant) can be illuminated and uncaged by violet light (405 nM), to release raseglurant with spatial and temporal precision and allow local modulation of mGlu5 receptors. Unlike other caged compounds, JF-NP-26 can be uncaged by light within the visible spectrum which is advantageous for translation studies.
JF-NP-26 (Caged-Raseglurant) is active in vivo, can be administered systemically and activated by LED-based illumination to induce JF-NP-26-mediated, light-dependent analgesia in both neuropathic and acute/tonic inflammatory pain models. No liver toxicity was observed in JF-NP-26 treatments used in tested pain models.
Storing and Using Your Product
Soluble in DMSO (100mM)
This compound is light sensitive; exposure to light may affect compound performance. We therefore recommend storing the material in the dark and protecting from light.
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
References for JF-NP-26 (Caged-Raseglurant)
Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator.Font et al (2017) ELife pii: e23545. : doi: 10.7554/eLife.23545.PubMedID: 28395733