Kynurenic acid sodium salt

(HB0363)

Product overview

  • Name
    Kynurenic acid sodium salt
  • Short description
    Endogenous ionotropic glutamate / nicotinic antagonist. Sodium salt.
  • Biological description
    Endogenous, non-selective ionotropic glutamate receptor antagonist which acts as a non-competitive glycine site NMDAR antagonist. Also an α7 nicotinic receptor antagonist and GPR35 ligand. Sodium salt. Blocks kainic acid neurotoxicity and displays neuroprotective, antiproliferative and antimigrative properties.
  • Biological action
    Antagonist
  • Purity
    >98%
  • Our products in action

Images

Properties

  • Chemical name
    4-Hydroxyquinoline-2-carboxylic acid sodium salt
  • Molecular Weight
    211.15
  • Chemical structure
    Kynurenic acid sodium salt  [2439-02-3]
  • Molecular Formula
    C10H6NNaO3
  • CAS Number
    2439-02-3
  • PubChem identifier
    52974250
  • SMILES
    C1=CC=C2C(=C1)C(=O)C=C(N2)C(=O)[O-].[Na+]
  • Source
    Synthetic
  • InChi
    InChI=1S/C10H7NO3.Na/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9;/h1-5H,(H,11,12)(H,13,14);/q;+1/p-1
  • InChiKey
    RCAZGXKUQDXSSK-UHFFFAOYSA-M
  • MDL number
    MFCD00006753
  • Appearance
    Pale solid

Applications

  • Application notes

    Kynurenic acid is commonly used as an AMPA/NMDA receptor antagonist. Kynurenic acid is commonly used at concentration of 10mM. Kynurenic acid from Hello Bio rapidly inhibits both NMDA and AMPA mediated spontaneous and evoked EPSCs at concentrations of 10mM (see Fig 1 above).

     

    #Protocol 1: Evoked NMDA receptor currents

    • Whole cell voltage clamp recordings were obtained from layer V neurons of the mouse prelimbic cortex brain slice.
    • NMDA currents were evoked via a stimulating electrode placed in layers II/III and evoked by a single square (150 μs) pulse every 10 sec at a stimulus intensity that gave a reliable NMDA current.
    • Neurons were held a +40 mV to relieve NMDA currents from their voltage-dependent Mg2+ block.
    • NMDA currents were continually stimulated and recorded in response to continual bath applications of NMDAR antagonists until NMDA currents were completely abolished. If the concentration was not effective an addition experiment was conducted using an alternative concentration.
    • All NMDAR recordings were made in the presence of GABAA-R and AMPAR antagonists.

     

     

Storing and Using Your Product

  • Storage instructions
    Room temperature (desiccate)
  • Solubility overview
    Soluble in water (100mM) or DMSO (50mM)

References for Kynurenic acid sodium salt

  • 6-Hydroxykynurenic acid and kynurenic acid differently antagonise AMPA and NMDA receptors in hippocampal neurones.

    Weber M et al (2001) J Neurochem 77(4) : 1108-15.
    PubMedID: 11359876
  • Kynurenic acid inhibits proliferation and migration of human glioblastoma T98G cells.

    Walczak K et al (2014) Pharmacol Rep 66(1) : 130-6.
    PubMedID: 24905318
  • Kynurenate is neuroprotective following experimental brain injury in the rat.

    Hicks RR et al (1994) Brain Res 655(1-2) : 91-6.
    PubMedID: 7812795
  • Pharmacological characterization of glutamatergic agonists and antagonists at recombinant human homomeric and heteromeric kainate receptors in vitro.

    Alt et al (2004) Neuropharmacology 46(6) : 793-806
    PubMedID: 15033339