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LDN193189 hydrochloride (LDN)


Product overview

  • Name
    LDN193189 hydrochloride (LDN)
  • Short description
    Potent, selective ALK2/ALK3 inhibitor which also promotes neural induction of hPSCs
  • Biological description

    LDN193189 hydrochloride is a potent and selective ALK2/ALK3 inhibitor (IC50 values are 5 and 30 nM) which inhibits BMP4-mediated Smad1/5/8 phosphorylation. It is a derivative of dorsomorphin.

    LDN193189 is frequently used in stem cell research. It promotes differentiation of neural progenitor cells from hPSCs.

  • Alternative names
  • Purity
  • Citations


  • Chemical name
    4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline hydrochloride
  • Molecular Weight
  • Chemical structure
    LDN 193189 hydrochloride [1435934-00-1]
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • InChi
  • InChiKey
  • Appearance
    Orange solid

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    Soluble in water (50 mM), and in DMSO (20 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

References for LDN193189 hydrochloride (LDN)

  • The specificities of small molecule inhibitors of the TGFß and BMP pathways.

    Vogt et al (2011) Cell Signal 23(11) : 1831-42
    PubMedID: 21740966
  • Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells.

    Boergermann et al (2010) Int J Biochem Cell Biol 42(11) : 1802-7
    PubMedID: 20691279
  • Small molecules dorsomorphin and LDN-193189 inhibit myostatin/GDF8 signaling and promote functional myoblast differentiation.

    Horbelt et al (2015) J Biol Chem 290(6) : 3390-404
    PubMedID: 25368322
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