In my cart

You have no items in your shopping cart.

LDN193189 dihydrochloride (LDN)

(HB5624)
Data

Product overview

  • Name
    LDN193189 dihydrochloride (LDN)
  • Short description
    Potent, selective ALK2/ALK3 inhibitor which also promotes neural induction of hPSCs
  • Biological description

    LDN193189 dihydrochloride is a potent and selective ALK2/ALK3 inhibitor (IC50 values are 5 and 30 nM) which inhibits BMP4-mediated Smad1/5/8 phosphorylation. It is a derivative of dorsomorphin.


    LDN193189 is frequently used in stem cell research. It promotes differentiation of neural progenitor cells from hPSCs.

  • Alternative names
    LDN
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
  • Molecular Weight
    479.4
  • Chemical structure
    LDN 193189 dihydrochloride [1435934-00-1]
  • Molecular Formula
    C25H22N6.2HCl
  • CAS Number
    1435934-00-1
  • PubChem identifier
    91900717
  • SMILES
    N1(C2=CC=C(C3=CN4N=CC(C5=CC=NC6=C5C=CC=C6)=C4N=C3)C=C2)CCNCC1.Cl.Cl
  • InChi
    InChI=1S/C25H22N6.2ClH/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30;;/h1-10,15-17,26H,11-14H2;2*1H
  • InChiKey
    CMQXLLAILGGLRV-UHFFFAOYSA-N
  • Appearance
    Orange solid

Storing and Using Your Product

  • Storage instructions
    Store at -20 °C
  • Solubility overview
    Soluble in water (50 mM), and in DMSO (20 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

References for LDN193189 dihydrochloride (LDN)

  • The specificities of small molecule inhibitors of the TGFß and BMP pathways.

    Vogt et al (2011) Cell Signal 23(11) : 1831-42
    PubMedID: 21740966
  • Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells.

    Boergermann et al (2010) Int J Biochem Cell Biol 42(11) : 1802-7
    PubMedID: 20691279
  • Small molecules dorsomorphin and LDN-193189 inhibit myostatin/GDF8 signaling and promote functional myoblast differentiation.

    Horbelt et al (2015) J Biol Chem 290(6) : 3390-404
    PubMedID: 25368322
Support & Resources