In my cart

You have no items in your shopping cart.

MTEP hydrochloride


Product overview

  • Name
    MTEP hydrochloride
  • Short description
    Potent, highly selective, non-competitive mGluR5 antagonist
  • Biological description

    MTEP hydrochloride is a potent, highly selective and non-competitive mGlu5 receptor antagonist (IC50 = 5 nM and Ki = 16 nM in an in vitro Ca2+-flux assay).

    MTEP has no significant effect on other mGluRs and shows fewer off-target effects than MPEP hydrochlorideMTEP shows ~10-fold greater selectivity for mGlu5 than MPEP.

    MTEP also blocks induction of tLTP (timing-dependent long term potentiation) and has antidepressant, anxiolytic and neuroprotective properties.

    MTEP is active in vivo.

  • Biological action
  • Purity
  • Citations



  • Chemical name
    3-((2-Methyl-1,3-thiazol-4-yl)ethynyl)pyridine hydrochloride
  • Molecular Weight
  • Chemical structure
    MTEP hydrochloride  [1186195-60-7]
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • Source
  • InChi
  • InChiKey
  • MDL number
  • Appearance
    Light cream solid

Storing and Using Your Product

  • Storage instructions
    +4°C (desiccate)
  • Solubility overview
    Soluble in water (100mM) and in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for MTEP hydrochloride

  • Neuroprotective potential of mGluR5 antagonist MTEP: effects on kainate-induced excitotoxicity in the rat hippocampus.

    Domin H et al (2010) Pharmacol Rep 62(6) : 1051-61.
    PubMedID: 21273662
  • NMDA but not AMPA glutamatergic receptors are involved in the antidepressant-like activity of MTEP during the forced swim test in mice.

    Pomierny-Chamioło L et al (2010) Pharmacol Rep 62(6) : 1186-90.
    PubMedID: 21273676
  • Metabotropic glutamate receptor 5 negative allosteric modulators as novel tools for in vivo investigation.

    Keck TM et al (2012) ACS Med Chem Lett 3(7) : 544-549.
    PubMedID: 22924094
  • Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP.

    Lea and Faden (2006) CNS Drug Rev. 12(2) : 149-66
    PubMedID: 16958988
  • Gating of NMDA receptor-mediated hippocampal spike timing-dependent potentiation by mGluR5.

    Kwag and Paulsen (2012) Neuropharmacology 63(4) : 701-9
    PubMedID: 22652057
Our products in action
The following papers have cited the use of MTEP hydrochloride (HB0431) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • An Appraisal of the Influence of the Metabotropic Glutamate 5 (mGlu5) Receptor on Sociability and Anxiety.

    Ramos-Prats et al (2019) Front Mol Neurosci. 19 : 12:30
    PubMedID: 30873001
Support & Resources