MTEP hydrochloride

(HB0431)

Product overview

  • Name
    MTEP hydrochloride
  • Short description
    Potent, highly selective, non-competitive mGluR5 antagonist
  • Biological description

    Potent, highly selective and non-competitive mGlu5 receptor antagonist (IC50 = 5 nM and Ki = 16 nM in an in vitro Ca2+-flux assay).

    Has no significant effect on other mGluRs and shows fewer off-target effects than MPEP hydrochlorideShows ~10-fold greater seletivity for mGlu5 than MPEP.

    Blocks induction of tLTP (timing-dependent long term potentiation) and has antidepressant, anxiolytic and neuroprotective properties. Active in vivo.

  • Biological action
    Antagonist
  • Purity
    >98%
  • Our products in action

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Properties

  • Chemical name
    3-((2-Methyl-1,3-thiazol-4-yl)ethynyl)pyridine hydrochloride
  • Molecular Weight
    236.72
  • Chemical structure
    MTEP hydrochloride  [1186195-60-7]
  • Molecular Formula
    C11H8N2S.HCl
  • CAS Number
    1186195-60-7
  • PubChem identifier
    45073467
  • SMILES
    CC1=NC(=CS1)C#CC2=CN=CC=C2.Cl
  • Source
    Synthetic
  • InChi
    InChI=1S/C11H8N2S.ClH/c1-9-13-11(8-14-9)5-4-10-3-2-6-12-7-10;/h2-3,6-8H,1H3;1H
  • InChiKey
    YCIOJDKGCWAHLR-UHFFFAOYSA-N
  • MDL number
    MFCD08458895
  • Appearance
    Light cream solid

Storing and Using Your Product

  • Storage instructions
    +4°C (desiccate)
  • Solubility overview
    Soluble in water (100mM) and in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for MTEP hydrochloride

  • Neuroprotective potential of mGluR5 antagonist MTEP: effects on kainate-induced excitotoxicity in the rat hippocampus.

    Domin H et al (2010) Pharmacol Rep 62(6) : 1051-61.
    PubMedID: 21273662
  • NMDA but not AMPA glutamatergic receptors are involved in the antidepressant-like activity of MTEP during the forced swim test in mice.

    Pomierny-Chamioło L et al (2010) Pharmacol Rep 62(6) : 1186-90.
    PubMedID: 21273676
  • Metabotropic glutamate receptor 5 negative allosteric modulators as novel tools for in vivo investigation.

    Keck TM et al (2012) ACS Med Chem Lett 3(7) : 544-549.
    PubMedID: 22924094
  • Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP.

    Lea and Faden (2006) CNS Drug Rev. 12(2) : 149-66
    PubMedID: 16958988
  • Gating of NMDA receptor-mediated hippocampal spike timing-dependent potentiation by mGluR5.

    Kwag and Paulsen (2012) Neuropharmacology 63(4) : 701-9
    PubMedID: 22652057