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ω-Conotoxin GVIA


Product overview

  • Name
    ω-Conotoxin GVIA
  • Short description
    Potent, selective Cav2.2 (N-type) channel blocker
  • Biological description
    Peptide toxin. Potent, selective, partially reversible Cav2.2 (N-type) channel blocker (IC50 = 0.15 nM). Binds Cav2.2 α1 subunit (α1B). Inhibits synaptic plasticity and shows hypotensive and bradycardic actions.
  • Alternative names
    ω-CTX, ω-CgTx; SNX-124
  • Biological action
  • Purity
  • Net peptide content
    73% (this peptide is sold by gross weight)
  • Special requirements
    As this product is a toxin, customers are required to complete a short end user declaration when ordering. Our customer care team will be happy to help you with this.
  • Citations


  • Chemical name
    H-Cys(1)-Lys-Ser-Hyp-Gly-Ser-Ser-Cys(2)-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys(3)-Cys(1)-Arg-Ser-Cys(2)-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys(3)-Tyr-NH2 trifluoroacetate salt
  • Molecular Weight
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • InChi
  • InChiKey
  • MDL number

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Solubility overview
    Soluble in water (1mg/ml)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for ω-Conotoxin GVIA

  • Complex structures between the N-type calcium channel (CaV2.2) and ω-conotoxin GVIA predicted via molecular dynamics.

    Chen R et al (2013) Biochemistry 52(21) : 3765-72.
    PubMedID: 23651160
  • Distinct mechanisms contribute to agonist and synaptically induced metabotropic glutamate receptor long-term depression.

    Connelly et al (2011) Eur J Pharmacol 667(1-3) : 160-8
    PubMedID: 21575629
  • The effect of omega-conotoxin GVIA on synaptic transmission within the nucleus accumbens and hippocampus of the rat in vitro.

    Home and Kemp (1991) Br J Pharmacol 103(3) : 1733-9
    PubMedID: 1657265
  • omega-Conotoxin reduces facilitation of transmitter release at the frog neuromuscular junction.

    Zengel et al (1993) Brain Res 611(1) : 25-30
    PubMedID: 8100174
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