(R,S)-3,5-DHPG

(HB0026)

Product overview

  • Name
    (R,S)-3,5-DHPG
  • Short description
    Selective group I (mGluR1 / mGluR5) agonist
  • Biological description

    (R,S)-3,5-DHPG is a elective group I mGluR (mGluR1 / mGluR5) agonist.


    (R,S)-3,5-DHPG stimulates phospholipase C (PLC) response and inhibits phospholipase D (PLD) response.

    (R,S)-3,5-DHPG also induces LTD in the hippocampus.


    The active enantiomer of DHPG:(S)-3,5-DHPG is also available.

  • Alternative names
    (RS)-3,5-Dihydroxyphenylglycine
  • Biological action
    Agonist
  • Purity
    >99%
  • Customer comments

    Getting on well with DHPG & picrotoxin – they do what they’re supposed to! Professor Bruno Frenguelli, University of Warwick, UK

  • Citations

Images

Properties

  • Chemical name
    (RS)-3,5-Dihydroxyphenylglycine
  • Molecular Weight
    183.16
  • Chemical structure
    (R,S)-3,5-DHPG  [19641-83-9]
  • Molecular Formula
    C8H9NO4
  • CAS Number
    19641-83-9
  • PubChem identifier
    108001
  • SMILES
    C1=C(C=C(C=C1O)O)C(C(=O)O)N
  • Source
    Synthetic
  • InChi
    InChI=1S/C8H9NO4/c9-7(8(12)13)4-1-5(10)3-6(11)2-4/h1-3,7,10-11H,9H2,(H,12,13)
  • InChiKey
    HOOWCUZPEFNHDT-UHFFFAOYSA-N
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Solubility overview
    Soluble in water (10mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for (R,S)-3,5-DHPG

  • Pharmacological characterization of metabotropic glutamate receptors coupled to phospholipase D in the rat hippocampus.

    Pellegrini-Giampietro DE et al (1996) Br J Pharmacol 118(4) : 1035-43.
    PubMedID: 8799579
  • The group I mGlu receptor agonist DHPG induces a novel form of LTD in the CA1 region of the hippocampus.

    Palmer MJ et al (1997) Neuropharmacology 36(11-12) : 1517-32.
    PubMedID: 9517422
  • Interaction of DHPG-LTD and synaptic-LTD at senescent CA3-CA1 hippocampal synapses.

    Kumar A et al (2014) Hippocampus 24(4) : 466-75.
    PubMedID: 24390964
The following papers have cited the use of (R,S)-3,5-DHPG (HB0026) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • mGluR-LTD at Excitatory and Inhibitory Synapses in the Lateral Habenula Tunes Neuronal Output.

    Valentinova and Mameli(2016) Cell Rep 16(9) : 2298-307
    PubMedID: 27545888