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Product overview

  • Name
  • Short description
    Selective group I (mGluR1 / mGluR5) agonist
  • Biological description

    (R,S)-3,5-DHPG is a selective group I mGluR (mGluR1 / mGluR5) agonist.

    (R,S)-3,5-DHPG stimulates phospholipase C (PLC) response and inhibits phospholipase D (PLD) response.

    (R,S)-3,5-DHPG also induces LTD in the hippocampus.

    The active enantiomer of DHPG: (S)-3,5-DHPG is also available.

  • Alternative names
  • Biological action
  • Purity
  • Customer comments

    Getting on well with DHPG & picrotoxin – they do what they’re supposed to! Professor Bruno Frenguelli, University of Warwick, UK

  • Citations



  • Chemical name
  • Molecular Weight
  • Chemical structure
    (R,S)-3,5-DHPG  [19641-83-9]
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • Source
  • InChi
  • InChiKey
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Solubility overview
    Soluble in water (10mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for (R,S)-3,5-DHPG

  • Pharmacological characterization of metabotropic glutamate receptors coupled to phospholipase D in the rat hippocampus.

    Pellegrini-Giampietro DE et al (1996) Br J Pharmacol 118(4) : 1035-43.
    PubMedID: 8799579
  • The group I mGlu receptor agonist DHPG induces a novel form of LTD in the CA1 region of the hippocampus.

    Palmer MJ et al (1997) Neuropharmacology 36(11-12) : 1517-32.
    PubMedID: 9517422
  • Interaction of DHPG-LTD and synaptic-LTD at senescent CA3-CA1 hippocampal synapses.

    Kumar A et al (2014) Hippocampus 24(4) : 466-75.
    PubMedID: 24390964
Our products in action
The following papers have cited the use of (R,S)-3,5-DHPG (HB0026) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • mGluR-LTD at Excitatory and Inhibitory Synapses in the Lateral Habenula Tunes Neuronal Output.

    Valentinova and Mameli(2016) Cell Rep 16(9) : 2298-307
    PubMedID: 27545888
  • The Probability of Neurotransmitter Release Governs AMPA Receptor Trafficking via Activity-Dependent Regulation of mGluR1 Surface Expression.

    Sanderson et al (2018) Cell Rep. 25(13) : 3631-3646
    PubMedID: 30590038
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