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Product overview

  • Name
  • Short description
    Selective group I mGlu receptor agonist. Induces LTD.
  • Biological description

    (S)-3,5-DHPG is a widely used selective group I mGlu receptor agonist (EC50 values are 2 and 6.6 µM at mGlu5 and mGlu1, 106 µM at mGlu3 and >1000 µM at mGlu2,4,7,8 receptors respectively).

    (S)-3,5-DHPG is the active enantiomer of DHPG. The racemic (R,S)-DHPG is also available.

    (S)-3,5-DHPG induces long term depression (LTD) (mGluR/DHPG-LTD). DHPG-LTD can temporarily be reversed by other mGluR antagonists such as (S)-MCPG.

    The CaMKII inhibitor KN-62 has also been shown to facilitate DHPG-LTD and (S)-3,5-DHPG-induced LTD is thought to involve rapid protein synthesis which can be antagonized by the protein synthesis inhibitor anisomycin.

    (S)-3,5-DHPG is active in vivo and shows a variety of biological actions.

  • Biological action
  • Purity
  • Citations



  • Chemical name
  • Molecular Weight
  • Chemical structure
    (S)-3,5-DHPG  [162870-29-3]
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • Source
  • InChi
  • InChiKey
  • MDL number
  • Appearance
    White solid


  • Application notes

    Figure 1: Gamma-frequency oscillations recorded in CA3 region of rat in vitro hippocampal slice preparation.


    Increase in gamma frequency oscillatory activity (dark blue) following (S)-3,5-DHPG application. Under control conditions there is no gamma activity (light blue). 

    Data kindly provided by Neurexpert

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Solubility overview
    Soluble in water (50mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for (S)-3,5-DHPG

  • Behavioral and convulsant effects of the (S) enantiomer of the group I metabotropic glutamate receptor agonist 3,5-DHPG in mice.

    Barton ME et al (2005) Neuropharmacology 48(6) : 779-87.
    PubMedID: 15829250
  • Face-washing behavior induced by the group I metabotropic glutamate receptor agonist (S)-3,5-DHPG in mice is mediated by mGlu1 receptor.

    Hikichi H et al (2008) Eur J Pharmacol 586(1-3) : 212-6.
    PubMedID: 18378225
  • (S)-3,5-DHPG: a review.

    Wiśniewski K et al (2002) CNS Drug Rev 8(1) : 101-16.
    PubMedID: 12070529
Our products in action
The following papers have cited the use of (S)-3,5-DHPG (HB0045) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • Mechanisms of synaptic zinc plasticity at mouse dorsal cochlear nucleus glutamatergic synapses

    Tzounopoulos and Vogler(2018) bioRxiv doi :
  • Activation of Serotonin 5-HT7 Receptors Modulates Hippocampal Synaptic Plasticity by Stimulation of Adenylate Cyclases and Rescues Learning and Behavior in a Mouse Model of Fragile X Syndrome.

    Costa et al (2018) Front Mol Neurosci. 11:353 : doi: 10.3389/fnmol.2018.00353
    PubMedID: 30333723
  • Chemical LTD, but not LTP, induces transient accumulation of gelsolin in dendritic spines.

    Hlushchenko and Hotulainen(2019) Biol Chem : doi: 10.1515/hsz-2019-0110.
    PubMedID: 31280237
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