Selective group I mGlu receptor agonist. Induces LTD.
(S)-3,5-DHPG is a widely used selective group I mGlu receptor agonist (EC50 values are 2 and 6.6 µM at mGlu5 and mGlu1, 106 µM at mGlu3 and >1000 µM at mGlu2,4,7,8 receptors respectively).
(S)-3,5-DHPG is the active enantiomer of DHPG. The racemic (R,S)-DHPG is also available.
(S)-3,5-DHPG induces long term depression (LTD) (mGluR/DHPG-LTD). DHPG-LTD can temporarily be reversed by other mGluR antagonists such as (S)-MCPG.
The CaMKII inhibitor KN-62 has also been shown to facilitate DHPG-LTD and (S)-3,5-DHPG-induced LTD is thought to involve rapid protein synthesis which can be antagonized by the protein synthesis inhibitor anisomycin.
(S)-3,5-DHPG is active in vivo and shows a variety of biological actions.
1 citation Submit Your Citation Now
Figure 1: Gamma-frequency oscillations recorded in CA3 region of rat in vitro hippocampal slice preparation.
Increase in gamma frequency oscillatory activity (dark blue) following (S)-3,5-DHPG application. Under control conditions there is no gamma activity (light blue).
Data kindly provided by Neurexpert
Storing and Using Your Product
Soluble in water (50mM)
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for (S)-3,5-DHPG
Behavioral and convulsant effects of the (S) enantiomer of the group I metabotropic glutamate receptor agonist 3,5-DHPG in mice.Barton ME et al (2005) Neuropharmacology 48(6) : 779-87.PubMedID: 15829250
Face-washing behavior induced by the group I metabotropic glutamate receptor agonist (S)-3,5-DHPG in mice is mediated by mGlu1 receptor.Hikichi H et al (2008) Eur J Pharmacol 586(1-3) : 212-6.PubMedID: 18378225
(S)-3,5-DHPG: a review.Wiśniewski K et al (2002) CNS Drug Rev 8(1) : 101-16.PubMedID: 12070529
Mechanisms of synaptic zinc plasticity at mouse dorsal cochlear nucleus glutamatergic synapsesTzounopoulos and Vogler(2018) bioRxiv doi : https://doi.org/10.1101/320671