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PEAQX (NVP-AAM 077)

(HB2841)
Technical documents: SDS CoA Datasheet

Product overview

Name PEAQX (NVP-AAM 077)
Alternative names NVP-AAM 007
Purity >98%
Customer comments

It works! PEAQX (NVP-AAM 077) blocks a considerable portion of the NMDA-mediated current in whole cell patch set-up. Verified customer, Rutgers University

Description Potent, competitive NMDA receptor antagonist
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PEAQX (NVP-AAM 077): Scientist Approved

Biological Data

Biological description

Potent and competitive NMDA receptor antagonist. Binds at the glutamate site.

Shows some selectivity (~7-10-fold) for GluN1/2A (NR1/2A) over GluN1/2B (NR1/2B) subunit containing receptors (IC50 values are 31 and 215 nM at GluN1/2A and GluN1/2B respectively).

Shows anticonvulsant activity. Active in vivo.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in water (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name [[[(1S)-1-(4-Bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl] phosphonic acid tetrasodium salt
Molecular Weight 542.14
Chemical structure PEAQX [459836-30-7] Chemical Structure
Molecular Formula C17H13BrN3Na4O5P
CAS Number 459836-30-7
PubChem identifier 101043065
SMILES CC(C1=CC=C(C=C1)Br)NC(C2=C3C(=CC=C2)N=C(C(=N3)[O-])[O-])P(=O)([O-])[O-].[Na+].[Na+].[Na+].[Na+]
InChi InChI=1S/C17H17BrN3O5P.4Na/c1-9(10-5-7-11(18)8-6-10)19-17(27(24,25)26)12-3-2-4-13-14(12)21-16(23)15(22)20-13;;;;/h2-9,17,19H,1H3,(H,20,22)(H,21,23)(H2,24,25,26);;;;/q;4*+1/p-4
InChiKey QBVOZIDKUFSQIL-UHFFFAOYSA-J

References for PEAQX (NVP-AAM 077)

References are publications that support the biological activity of the product
  • The effects of an acute challenge with the NMDA receptor antagonists, MK-801, PEAQX, and ifenprodil, on social inhibition in adolescent and adult male rats.

    Morales and Spear (2014) Psychopharmacology (Berl). 231(8) : 1797-807
  • Equilibrium constants for (R)-[(S)-1-(4-bromo-phenyl)-ethylamino]-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-methyl]-phosphonic acid (NVP-AAM077) acting at recombinant NR1/NR2A and NR1/NR2B NMDA receptors: Implications for studies of sy

    Frizelle et al (2006) Mol Pharmacol. 70(3) : 1022-32
  • 5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition.

    Auberson et al (2002) Bioorg Med Chem Lett 12(7) : 1099-102.

3 Item(s)

Publications
These publications cite the use of PEAQX (NVP-AAM 077) purchased from Hello Bio:
  • Cellular and Molecular Changes in Hippocampal Glutamate Signaling and Alterations in Learning, Attention, and Impulsivity Following Prenatal Nicotine Exposure

    Polli et al. (2020) Mol Neurobiol 57(4) : 2002-2020
    PubMedID: 31916029
  • Structural basis of subunit selectivity for competitive NMDA receptor antagonists with preference for GluN2A over GluN2B subunits.

    Lind et al (2017) Proc Natl Acad Sci U S A 114(33) : 6942-6951
    PubMedID: 28760974
  • Structural basis of subunit selectivity for competitive NMDA receptor antagonists with preference for GluN2A over GluN2B subunits.

    Lind et al (2017) Proc Natl Acad Sci U S A. doi: 10.1073/pnas.1707752114 : Epub ahead of print
    PubMedID: 28760974

3 Item(s)