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PEAQX (NVP-AAM 077)

(HB2841)
Data

Product overview

  • Name
    PEAQX (NVP-AAM 077)
  • Short description
    Potent, competitive NMDA receptor antagonist
  • Biological description

    Potent and competitive NMDA receptor antagonist. Binds at the glutamate site.

    Shows some selectivity (~7-10-fold) for GluN1/2A (NR1/2A) over GluN1/2B (NR1/2B) subunit containing receptors (IC50 values are 31 and 215 nM at GluN1/2A and GluN1/2B respectively).

    Shows anticonvulsant activity. Active in vivo.

  • Alternative names
    NVP-AAM 007
  • Biological action
    Antagonist
  • Purity
    >98%
  • Customer comments

    It works! PEAQX (NVP-AAM 077) blocks a considerable portion of the NMDA-mediated current in whole cell patch set-up. Verified customer, Rutgers University

  • Citations

Images

Properties

  • Chemical name
    [[[(1S)-1-(4-Bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl] phosphonic acid tetrasodium salt
  • Molecular Weight
    542.14
  • Chemical structure
    PEAQX [459836-30-7]
  • Molecular Formula
    C17H13BrN3Na4O5P
  • CAS Number
    459836-30-7
  • PubChem identifier
    101043065
  • SMILES
    CC(C1=CC=C(C=C1)Br)NC(C2=C3C(=CC=C2)N=C(C(=N3)[O-])[O-])P(=O)([O-])[O-].[Na+].[Na+].[Na+].[Na+]
  • InChi
    InChI=1S/C17H17BrN3O5P.4Na/c1-9(10-5-7-11(18)8-6-10)19-17(27(24,25)26)12-3-2-4-13-14(12)21-16(23)15(22)20-13;;;;/h2-9,17,19H,1H3,(H,20,22)(H,21,23)(H2,24,25,26);;;;/q;4*+1/p-4
  • InChiKey
    QBVOZIDKUFSQIL-UHFFFAOYSA-J

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    Soluble in water (10mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for PEAQX (NVP-AAM 077)

  • 5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition.

    Auberson et al (2002) Bioorg Med Chem Lett 12(7) : 1099-102.
    PubMedID: 11909726
  • Equilibrium constants for (R)-[(S)-1-(4-bromo-phenyl)-ethylamino]-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-methyl]-phosphonic acid (NVP-AAM077) acting at recombinant NR1/NR2A and NR1/NR2B NMDA receptors: Implications for studies of sy

    Frizelle et al (2006) Mol Pharmacol. 70(3) : 1022-32
    PubMedID: 16778008
  • The effects of an acute challenge with the NMDA receptor antagonists, MK-801, PEAQX, and ifenprodil, on social inhibition in adolescent and adult male rats.

    Morales and Spear (2014) Psychopharmacology (Berl). 231(8) : 1797-807
    PubMedID: 24043344
Our products in action
The following papers have cited the use of PEAQX (NVP-AAM 077) (HB2841) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • Structural basis of subunit selectivity for competitive NMDA receptor antagonists with preference for GluN2A over GluN2B subunits.

    Lind et al(2017) Proc Natl Acad Sci U S A. doi: 10.1073/pnas.1707752114 : Epub ahead of print
    PubMedID: 28760974
Support & Resources

Reviews

  • Verified customer, Rutgers University

    It works! PEAQX (NVP-AAM 077) blocks a considerable portion of the NMDA-mediated current in whole cell patch set-up.
  • Verified customer, The University of Montana

    Great product for a low cost! We have recently used PEAQX (NVP-AAM 077) from Hello Bio to identify structural determinants of subunit-selectivity for competitive glutamate site NMDA receptor antagonists.