Novel tool for studying GPCR desensitization
An exclusive from Hello Bio, Cmpd101 is a novel, potent, selective G-protein coupled receptor kinase 2 and 3 inhibitor (IC50 values are 35, 290 nM and 125 µM at GRK2, GRK3 and GRK5 respectively). Selective over other kinases. Can be used to study roles of GRK2/3 in GPCR desensitization...Read more
NMDA receptors (NMDARs) are voltage-dependent and ligand-gated ionotropic glutamate receptors that also require co-activation with glycine or D-serine. NMDA receptors are heterotetrameric and are comprised of GluN1, GluN2 (GluN2A, GluN2B, GluN2C, GluN2D), and GluN3 (GluN3A, GluN3B) subunits. Researchers can save 50% on NMDA receptor (NMDAR) agonists, antagonists, positive allosteric modulators (PAMs) and negative allosteric modulators (NAMs) from Hello Bio- they are up to half the price of other suppliers.