Metabotropic glutamate receptors (mGluRs) are GPCRs with important roles in learning and memory, pain, epilepsy and more. Selective agonists, antagonists, and positive and negative allosteric modulators (PAMs and NAMs) have been developed for Group I (mGlu1 and mGlu5), Group II (mGlu2 and mGlu3) and Group III (mGlu4, mGlu6, mGlu7 and mGlu8) receptors. This mini-review summarises the structure, function and pharmacology of mGluRs to date...
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NMDA receptors (NMDARs) are voltage-dependent and ligand-gated ionotropic glutamate receptors that also require co-activation with glycine or D-serine. NMDA receptors are heterotetrameric and are comprised of GluN1, GluN2 (GluN2A, GluN2B, GluN2C, GluN2D), and GluN3 (GluN3A, GluN3B) subunits. Researchers can save 50% on NMDA receptor (NMDAR) agonists, antagonists, positive allosteric modulators (PAMs) and negative allosteric modulators (NAMs) from Hello Bio- they are up to half the price of other suppliers.