Novel tool for studying GPCR desensitization
An exclusive from Hello Bio, Cmpd101 is a novel, potent, selective G-protein coupled receptor kinase 2 and 3 inhibitor (IC50 values are 35, 290 nM and 125 µM at GRK2, GRK3 and GRK5 respectively). Selective over other kinases. Can be used to study roles of GRK2/3 in GPCR desensitization...Read more
GABAB receptors are metabotropic G-protein-coupled receptors.They exist as heterodimers of GABAB1 and GABAB2 subunits and the presence of both subunits is required for receptor function. Researchers can save 50% on GABAB receptor agonists, antagonists and allosteric modulators from Hello Bio - they are up to half the price of other suppliers.