Metabotropic glutamate receptors (mGluRs) are GPCRs with important roles in learning and memory, pain, epilepsy and more. Selective agonists, antagonists, and positive and negative allosteric modulators (PAMs and NAMs) have been developed for Group I (mGlu1 and mGlu5), Group II (mGlu2 and mGlu3) and Group III (mGlu4, mGlu6, mGlu7 and mGlu8) receptors. This mini-review summarises the structure, function and pharmacology of mGluRs to date...
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Metabotropic glutamate receptors are G-protein coupled receptors, classified into Group I (mGlu1, mGlu5), Group II (mGlu2, mGlu3), and Group III (mGlu4, mGlu6, mGlu7, mGlu8) receptors. Researchers can save 50% on metabotropic glutamate receptor agonists, antagonists, positive allosteric modulators (PAMs) and negative allosteric modulators (NAMs) from Hello Bio - they are up to half the price of other suppliers.