QX 314 bromide

(HB1029)

Product overview

  • Name
    QX 314 bromide
  • Short description
    Membrane impermeable Na+ channel blocker
  • Biological description

    Membrane impermeable Na+ channel blocker. A quaternary derivative of lidocaine. Reduces amplitude of high threshold Ca2+ currents in CA1 neurons. Displays anesthetic properties. QX 314 chloride also available.

  • Alternative names
    N-Ethyllidocaine bromide
  • Biological action
    Blocker
  • Purity
    >98%
  • Citations

Images

Properties

  • Chemical name
    N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium bromide
  • Molecular Weight
    343.31
  • Chemical structure
    QX 314 bromide  [24003-58-5]
  • Molecular Formula
    C16H27N2OBr
  • CAS Number
    24003-58-5
  • PubChem identifier
    9884487
  • SMILES
    CC[N+](CC)(CC)CC(=O)NC1=C(C=CC=C1C)C.[Br-]
  • Source
    Synthetic
  • InChi
    InChI=1S/C16H26N2O.BrH/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;/h9-11H,6-8,12H2,1-5H3;1H
  • InChiKey
    DLHMKHREUTXMCH-UHFFFAOYSA-N
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    Room temperature (desiccate)
  • Solubility overview
    Soluble in water (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for QX 314 bromide

  • Intracellular QX-314 inhibits calcium currents in hippocampal CA1 pyramidal neurons.

    Talbot MJ et al (1996) J Neurophysiol 76(3) : 2120-4.
    PubMedID: 8890325
  • Fast sodium action potentials are generated in the distal apical dendrites of rat hippocampal CA1 pyramidal cells.

    Colling SB et al (1994) Neurosci Lett 172(1-2) : 73-96.
    PubMedID: 8084540
  • The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine.

    Strichartz GR (1973) J Gen Physiol 62(1) : 37-57.
    PubMedID: 4541340
The following papers have cited the use of QX 314 bromide (HB1029) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • PAR1 activation induces rapid changes in glutamate uptake and astrocyte morphology.

    Sweeny et al (2017) Sci Rep. 7 : 43606
    PubMedID: 28256580

Reviews & Product Guides

Reviews

  • Verified customer, Seoul National University

    Very excellent Hello Bio!! Thanks for your services. Very fast delivery system is fancy!!