In my cart

You have no items in your shopping cart.

Ro 25-6981 maleate


Product overview

  • Name
    Ro 25-6981 maleate
  • Short description
    Selective negative allosteric modulator of GluN2B (NR2B) containing NMDARs
  • Biological description

    Ro 25-6981 maleate is a selective negative allosteric modulator (NAM) of GluN2B (NR2B) containing NMDARs.

    Ro 25-6981 maleate exhibits >5000-fold selectivity at GluN1C-GluN2B over GluN1C-GluN2A (IC50 values are 9 nM and 52 µM). Ro 25-6981 maleate shows neuroprotective properties.

  • Biological action
  • Purity
  • Citations


  • Chemical name
    RS)-α-(4-Hydroxyphenyl)-β-methyl-4- (phenylmethyl)-1-piperidinepropanol maleate
  • Molecular Weight
  • Chemical structure
    Ro 25-6981  [1312991-76-6]
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • Source
  • InChi
  • InChiKey
  • MDL number
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    Room temperature (desiccate)
  • Solubility overview
    Soluble in water (10mM, gentle warming) and in DMSO (100mM)
  • Handling
    Hydroscopic solid, contact with air may cause material to become sticky. Product performance should not be affected but we recommend storing the material in a sealed jar.
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Ro 25-6981 maleate

  • Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro.

    Fischer G et al (1997) J Pharmacol Exp Ther 283(3) : 1285-92.
    PubMedID: 9400004
  • The NR2B-selective N-methyl-D-aspartate receptor antagonist Ro 25-6981 [(+/-)-(R*,S*)-alpha-(4-hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidine propanol] potentiates the effect of nicotine on locomotor activity and dopamine release in the nucleus

    Kosowski AR et al (2004) J Pharmacol Exp Ther 311(2) : 560-7.
    PubMedID: 15256539
  • Pharmacological characterization of interactions of RO 25-6981 with the NR2B (epsilon2) subunit.

    Lynch DR et al (2001) Eur J Pharmacol 416(3) : 185-95.
    PubMedID: 11290368
Our products in action
The following papers have cited the use of Ro 25-6981 maleate (HB0554) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • Differential Regulation of Evoked and Spontaneous Release by Presynaptic NMDA Receptors

    Abrahamsson et al(2017) Neuron 09 : 030
    PubMedID: 29033205
Support & Resources


  • Verified customer

    Works fine - Ro 25-6981 maleate works fine dissolved in 1 part DMSO and 2 parts saline for i.p. injections in rats. Wish it came in larger quantities like 100mg.
  • Verified customer

    Reasonable price and it works as it should.
  • Verified customer

    Works for i.p. injections. We dissolved Ro 25-6981 in 1 part DMSO and 2 parts saline. The solution was fine to i.p. inject into rats.