Ro 25-6981 maleate

(HB0554)

Product overview

  • Name
    Ro 25-6981 maleate
  • Short description
    Selective negative allosteric modulator of GluN2B (NR2B) containing NMDARs
  • Biological description

    Selective negative allosteric modulator of GluN2B (NR2B) containing NMDARs.

    Exhibits >5000-fold selectivity at GluN1C-GluN2B over GluN1C-GluN2A (IC50 values are 9 nM and 52 µM). Shows neuroprotective properties.

  • Biological action
    NAM
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    RS)-α-(4-Hydroxyphenyl)-β-methyl-4- (phenylmethyl)-1-piperidinepropanol maleate
  • Molecular Weight
    455.55
  • Chemical structure
    Ro 25-6981  [1312991-76-6]
  • Molecular Formula
    C22H29NO2.C4H4O4
  • CAS Number
    1312991-76-6
  • PubChem identifier
    53250677
  • SMILES
    C[C@@H](CN1CCC(CC1)CC2=CC=CC=C2)[C@H](C3=CC=C(C=C3)O)O.C(=C\C(=O)O)\C(=O)O
  • Source
    Synthetic
  • InChi
    InChI=1S/C22H29NO2.C4H4O4/c1-17(22(25)20-7-9-21(24)10-8-20)16-23-13-11-19(12-14-23)15-18-5-3-2-4-6-18;5-3(6)1-2-4(7)8/h2-10,17,19,22,24-25H,11-16H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t17-,22+;/m0./s1
  • InChiKey
    FYJZEHCQSUBZDY-SEELMCCHSA-N
  • MDL number
    MFCD06798375
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    Room temperature (desiccate)
  • Solubility overview
    Soluble in water (10mM, gentle warming) and in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Ro 25-6981 maleate

  • Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro.

    Fischer G et al (1997) J Pharmacol Exp Ther 283(3) : 1285-92.
    PubMedID: 9400004
  • The NR2B-selective N-methyl-D-aspartate receptor antagonist Ro 25-6981 [(+/-)-(R*,S*)-alpha-(4-hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidine propanol] potentiates the effect of nicotine on locomotor activity and dopamine release in the nucleus

    Kosowski AR et al (2004) J Pharmacol Exp Ther 311(2) : 560-7.
    PubMedID: 15256539
  • Pharmacological characterization of interactions of RO 25-6981 with the NR2B (epsilon2) subunit.

    Lynch DR et al (2001) Eur J Pharmacol 416(3) : 185-95.
    PubMedID: 11290368