Product overview

  • Name
    (RS)-MCPG
  • Short description
    Non-selective group I and II mGluR antagonist
  • Biological description

    Non-selective group I and II mGluR antagonist.

    Also competitive antagonist of ACPD sensitive receptors.

    Shows no effect on locomotor activity.

    Water soluble (R,S)-MCPG sodium salt and (S)-MCPG sodium salt also available. (S)-MCPG also available.

  • Biological action
    Antagonist
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    (RS)-α-Methyl-4-carboxyphenylglycine
  • Molecular Weight
    209.2
  • Chemical structure
    (RS)-MCPG  [146669-29-6]
  • Molecular Formula
    C10H11NO4
  • CAS Number
    146669-29-6
  • PubChem identifier
    1222
  • SMILES
    CC(C1=CC=C(C=C1)C(=O)O)(C(=O)O)N
  • Source
    Synthetic
  • InChi
    InChI=1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15)
  • InChiKey
    DNCAZYRLRMTVSF-UHFFFAOYSA-N
  • MDL number
    MFCD00210205
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in 0.1M NaOH (100mM)

References for (RS)-MCPG

  • The metabotropic glutamate receptor antagonist (RS)-MCPG produces hyperlocomotion in amphetamine pre-exposed rats.

    Kim JH et al (1998) Neuropharmacology 37(2) : 189-97.
    PubMedID: 9680243
  • MCPG antagonizes metabotropic glutamate receptors but not long-term potentiation in the hippocampus.

    Manzoni OJ et al (1994) Eur J Neurosci 6(6) : 1050-4.
    PubMedID: 7952274
  • Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine and (RS)-alpha-methyl-4-carboxyphenylglycine.

    Eaton SA et al (1993) Eur J Pharmacol 244(2) : 195-7.
    PubMedID: 8381746