Selective TGF-βRI (ALK5), ALK4 and ALK7 inhibitor. Maintains human induced pluripotent stem cell (hiPSC) self renewal.
A 83-01 is a selective TGF-βRI (ALK5), ALK4 and ALK7 inhibitor (IC50 values are 12, 45 and 7.5 nM at ALK5, ALK4 and ALK7 respectively).
A 83-01 aids reprogramming of fibroblasts into neural stem cells and cardiomyocytes.
A 83-01 blocks phosphorylation of SMAD2/3 to inhibit TGF-β-induced epithelial-to-mesenchymal transition
Maintenance / self-renewal
A 83-01 helps to maintain homogeneity and long-term in vitro self-renewal of iPSCs
Pale yellow solid
Storing and Using Your Product
-20°C (protect from light)
Soluble in DMSO (50mM)
- This compound is light sensitive; we therefore recommend protecting the solid material and solutions from exposure to light.
- It has been reported that A 83-01 can decompose to A 77-01 in solution. We therefore recommend that you make up solutions and use immediately. Do not store solutions.
- If storage of solutions is required, you should aliquot out the solution into tightly sealed vials and store at -20°C and store these for up to one month.
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for A 83-01
The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta.Tojo et al (2005) Cancer Sci 96(11) : 791-800PubMedID: 16271073
Brief report: combined chemical treatment enables Oct4-induced reprogramming from mouse embryonic fibroblasts.Yuan et al (2011) 2011 29(3) : 549-53PubMedID: 21425417
Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors.Li et al (2009) Cell Stem Cell 4(1) : 16-9PubMedID: 19097958
Chemical compound-based direct reprogramming for future clinical applications.Takeda et al (2018) Biosci Rep 38(3) : pii: BSR20171650PubMedID: 29739872