A 83-01

(HB3218)

Product overview

  • Name
    A 83-01
  • Short description
    Selective TGF-βRI (ALK5), ALK4 and ALK7 inhibitor. Maintains human induced pluripotent stem cell (hiPSC) self renewal.
  • Biological description
    Selective TGF-βRI (ALK5), ALK4 and ALK7 inhibitor (IC50 values are 12, 45 and 7.5 nM at ALK5, ALK4 and ALK7 respectively). Inhibits rat induced pluripotent stem cells (rIPSCs) and maintains hiPSC self renewal.
  • Alternative names
    A83
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    3-(6-Methyl-2-pyridinyl)-N-phenyl-4 -(4-quinolinyl)-1H-pyrazole-1-carbothioamide
  • Molecular Weight
    421.52
  • Molecular Formula
    C25H19N5S
  • CAS Number
    909910-43-6

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    soluble in DMSO (50mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for A 83-01

  • The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta.

    Tojo et al (2005) Cancer Sci 96(11) : 791-800
    PubMedID: 16271073
  • Brief report: combined chemical treatment enables Oct4-induced reprogramming from mouse embryonic fibroblasts.

    Yuan et al (2011) 2011 29(3) : 549-53
    PubMedID: 21425417
  • Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors.

    Li et al (2009) Cell Stem Cell 4(1) : 16-9
    PubMedID: 19097958