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Data

Product overview

  • Name
    Forskolin
  • Short description
    Cell permeable, reversible adenylyl cyclase activator. Neuronal differentiation inducer.
  • Biological description
    Cell permeable, reversible adenylyl cyclase activator. Increases cAMP levels and inhibits platelet-activating factor (PAF). Also inhibits mast cell degranulation and lowers intraocular pressure. Neuronal differentiation inducer. Displays vasodilating and hypotensive properties.
  • Biological action
    Activator
  • Customer comments

    I am currently working with forskolin. The quality of product and service is very satisfying. I am very happy to have access to your high quality products. Pojeong Park, PhD student, University of Bristol, UK

    Very satisfied with this product, it works as expected in our liver tumouroid cultures. Hello Bio are a fantastic company that keep you informed of your order throughout the delivery process. Also a fan of the datasheets they provide. Verified customer, UK

  • Citations

Properties

  • Chemical name
    [3R-(3<α,4aβ,5β,6β,6aα,10α,10aβ,10bα)]-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one
  • Molecular Weight
    410.51
  • Chemical structure
    Forskolin  [66575-29-9]
  • Molecular Formula
    C22H34O7
  • CAS Number
    66575-29-9
  • PubChem identifier
    47936
  • SMILES
    CC(=O)O[C@H]1[C@H]([C@@H]2[C@]([C@H](CCC2(C)C)O)([C@@]3([C@@]1(O[C@@](CC3=O)(C)C=C)C)O)C)O
  • InChi
    InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1
  • InChiKey
    OHCQJHSOBUTRHG-KGGHGJDLSA-N
  • MDL number
    MFCD00082317

Applications

  • Application notes

    Figures 1 - 3 show liver hepatocellular carcinoma tumouroids cultured with forskolin and A 83-01

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Solubility overview
    Soluble in DMSO (25 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Forskolin

  • Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signaling.

    Insel PA et al (2003) Cell Mol Neurobiol 23(3) : 305-14.
    PubMedID: 12825829
  • Forskolin and derivatives as tools for studying the role of cAMP.

    Alasbahi RH et al (2012) Pharmazie 67(1) : 5-13.
    PubMedID: 22393824
  • Forskolin: upcoming antiglaucoma molecule.

    Wagh VD et al (2012) J Postgrad Med 58(3) : 199-202.
    PubMedID: 23023353
  • Interactions of forskolin and adenylate cyclase. Effects on substrate kinetics and protection against inactivation by heat and N-ethylmaleimide.

    Awad JA et al (1983) J Biol Chem 258(5) : 2960-5.
    PubMedID: 6681815
Support & Resources

Reviews

  • Verified customer

    Very satisfied with this product, it works as expected in our liver tumouroid cultures. Hello Bio are a fantastic company that keep you informed of your order throughout the delivery process. Also a fan of the datasheets they provide.
  • Verified customer, University of Bristol

    I am currently working with forskolin. The quality of product and service is very satisfying. I am very happy to have access to your high quality products.