Clozapine N-oxide (CNO) (water soluble)

(HB1807)

Product overview

  • Name
    Clozapine N-oxide (CNO) (water soluble)
  • Short description
    Water soluble muscarinic DREADD receptor activator. Inert clozapine metabolite.
  • Biological description

    Water soluble, prototypical chemical actuator for Gq-DREADDs. Inert metabolite of the atypical antipsychotic clozapine.

    Activates the Gi-DREADD receptors: hM3Dq, hM1Dq and hM5Dq. Activation of hM3Dq elicits burst firing in neurons.

    CNO also activates the hM4Di and hM2Di Gq-DREADD receptors. Activation of hM4Di silences neuronal activity.

    Clozapine N-oxide has rapid CNS penetration and distribution and allows minimally invasive delivery - CNO can be administered via drinking water, itraperitoneal injection or directly infused intracranially.

  • Alternative names
    CNO
  • Biological action
    Activator
  • Purity
    >98%
  • Customer comments

    The Clozapine N-oxide (CNO) worked perfectly! It dissolved completely in saline at the dose I am using so no problems there! Verified customer, Istituto Italiano di Tecnologia

    The clozapine N-oxide dissolves perfectly in saline, even at a high dose! Verified customer, Radboud University

  • Our products in action

Properties

  • Chemical name
    8-Chloro-11-(4-methyl-4-oxido-1-pip erazinyl)-5H-dibenzo[b,e][1,4]diazepine
  • Molecular Weight
    342.82
  • Chemical structure
    Clozapine N-oxide | [34233-69-7]
  • Molecular Formula
    C18H19ClN4O
  • CAS Number
    34233-69-7
  • PubChem identifier
    2819
  • SMILES
    C[N+]1(CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl)[O-]
  • Source
    Synthetic
  • InChi
    InChI=1S/C18H19ClN4O/c1-23(24)10-8-22(9-11-23)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,21H,8-11H2,1H3
  • InChiKey
    WYRDWWAASBTJLM-UHFFFAOYSA-N
  • MDL number
    MFCD00210190
  • Appearance
    Yellow solid

Storing and Using Your Product

  • Storage instructions
    Room temperature (desiccate)
  • Solubility overview
    Soluble in water (100mM)
  • Handling

    On rare occasions crystallisation of concentrated solutions may occur and so we recommend the following guidelines:

    Solutions should be made up and used on the same day if possible. Making and handling of solutions should be conducted in a dust free environment and ensure that product and solvents are at ambient temperature before use. Please take care to ensure that your product is completely dissolved before use.

References for Clozapine N-oxide (CNO) (water soluble)

  • Novel designer receptors to probe GPCR signaling and physiology.

    Wess et al (2013) Trends Pharmacol Sci. 34(7) : 385-92
    PubMedID: 23769625
  • Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand.

    Arbruster et al (2007) Proc Natl Acad Sci U S A. 104(12) : 5163-8
    PubMedID: 17360345
  • The role of M1 muscarinic receptor agonism of N-desmethylclozapine in the unique clinical effects of clozapine.

    Weiner et al (2004) Psychopharmacology (Berl). 177(1-2) : 207-16
    PubMedID: 15258717

Reviews

  • Verified customer, Radboud University

    The clozapine N-oxide dissolves perfectly in saline, even at a high dose!
  • Verified customer, Istituto Italiano di Tecnologia

    The Clozapine N-oxide (CNO) worked perfectly! It dissolved completely in saline at the dose I am using so no problems there!