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Product overview

  • Name
  • Short description
    Competitive NMDA receptor antagonist
  • Biological description

    DL-AP5 is a competitive NMDA receptor antagonist which binds at the glutamate site.

    Impairs learning and fear conditioning.

    Water soluble DL-AP5 sodium salt also available.

  • Alternative names
  • Biological action
  • Purity
  • Citations



  • Chemical name
    DL-2-Amino-5-phosphonopentanoic acid
  • Molecular Weight
  • Chemical structure
    DL-AP5  [76326-31-3]
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • Source
  • InChi
  • InChiKey
  • MDL number
  • Appearance
    White solid


  • Application notes

    DL-AP5 from Hello Bio reduces the evoked NMDAR current at concentrations of 1 and 10 μM with full receptor antagonism achieved at 50 μM (see Fig 1 above). It was dissolved in water at 10 mM.


    #Protocol 1: Evoked NMDA receptor currents

    • Whole cell voltage clamp recordings were obtained from layer V neurons of the mouse prelimbic cortex brain slice.
    • NMDA currents were evoked via a stimulating electrode placed in layers II/III and evoked by a single square (150 μs) pulse every 10 sec at a stimulus intensity that gave a reliable NMDA current.
    • Neurons were held a +40 mV to relieve NMDA currents from their voltage-dependent Mg2+ block.
    • NMDA currents were continually stimulated and recorded in response to continual bath applications of DL-AP5 until NMDA currents were completely abolished.
    • All NMDAR recordings were made in the presence of GABAA-R and AMPAR antagonists.

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in water (10mM) or 0.1M NaOH (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for DL-AP5

  • Infusion of the NMDA receptor antagonist, DL-APV, into the basolateral amygdala disrupts learning to fear a novel and a familiar context as well as relearning to fear an extinguished context.

    Laurent V et al (2009) Learn Mem 16(1) : 96-105.
    PubMedID: 19141468
  • The basolateral amygdala is necessary for learning but not relearning extinction of context conditioned fear.

    Laurent V et al (2008) Learn Mem 15(5) : 304-14.
    PubMedID: 18463174
  • Comparative analysis of different competitive antagonists interaction with NR2A and NR2B subunits of NMDA ionotropic glutamate receptor.

    Blaise MC et al (2005) J Mol Model 11(6) : 489-502.
    PubMedID: 15928921
  • Context-Dependent Modulation of Excitatory Synaptic Strength by Synaptically Released Zinc

    Kalappa and Tzounopoulos (2017) eNeuro 10.1523 : 0011-17
Our products in action
The following papers have cited the use of DL-AP5 (HB0251) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • Context-Dependent Modulation of Excitatory Synaptic Strength by Synaptically Released Zinc

    Kalappa and Tzounopoulos(2017) eNeuro 10.1523 : 0011-17
  • PAR1 activation induces rapid changes in glutamate uptake and astrocyte morphology.

    Sweeny et al (2017) Sci Rep. 7 : 43606
    PubMedID: 28256580
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