Caged glutamate that rapidly and efficiently releases glutamate when photolysed
Caged glutamate that rapidly and efficiently releases glutamate when photolysed (300 - 380 nm excitation).
Peak absorption is at 340 nm, the quantum yield is 0.085 and photo release following a light pulse has a half-time of 200 ns.
MNI-caged-L-Glutamate is inactive at glutamate receptors and transporters at mM concentrations but does interfere with synpatic activation of GABAA receptors (IC50 = ~0.5 mM).
MNI-caged-L-Glutamate is water soluble, resistant to hydrolysis and stable at neutral pH.
MNI-Glu, Caged glutamate, MNI-Glutamate,
We confirmed Hello Bio MNI-caged-glutamate works very well for our two-photon uncaging experiment. I would be very happy to recommend your MNI glutamate. Verified customer
We are very pleased to have such a company like yours that offers products like MNI-caged-glutamate (MNI-Glu) at a very good price and still with a high quality. So we will rate your product 5 stars! Verified customer, LIN, Magdeburg
Storing and Using Your Product
-20 °C (protect from light)
Soluble in water (50mM) with gentle warming
- This compound is light sensitive; exposure to light may affect compound performance. We therefore recommend storing the material in the dark and protecting from light.
- Although stable to hydrolysis and soluble in water (50 mM) it is often necessary to warm stock solutions after thawing.
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for MNI-caged-L-Glutamate
Photochemical and pharmacological evaluation of 7-nitroindolinyl-and 4-methoxy-7-nitroindolinyl-amino acids as novel, fast caged neurotransmitters.Canepari et al (2001) J Neurosci Methods 112(1) : 29-42PubMedID: 11640955
Comparative analysis of inhibitory effects of caged ligands for the NMDA receptor.Maier et al (2005) J Neurosci Methods 142(1) : 1-9PubMedID: 15652611
New caged neurotransmitter analogs selective for glutamate receptor sub-types based on methoxynitroindoline and nitrophenylethoxycarbonyl caging groups.Palma-Cerda et al (2012) Neuropharmacology 63(4) : 624-34PubMedID: 22609535
Reviews & Product Guides
Works very well. We will be buying MNI-caged glutamate from Hello Bio from now on. We are happy that MNI-caged glutamate from Hello Bio works well for slice electrophysiological recordings in our focal laser stimulation experiments with DPSS laser (350nm).
We are very happy with the quality and price of the MNI-caged-L-glutamate (MNI-Glu) from Hello Bio.
We are currently using the compound to study dendritic integration, by uncaging MNI-Glu on multiple dendritic spines of hippocampal cells in acute brain slices. We are very excited about the potential results.
Experiments using MNI-Glu are more often very expensive, especially if one chooses to apply the compound in the bath in order to have a more stable and homogenous concentration. We are very pleased to have such a company like yours that offers products like MNI-caged-L-glutamate at a very good price and still with a high quality.
So we will rate your product 5 stars!
We confirmed Hello Bio MNI-caged-L-glutamate (MNI-glu) works very well for our two-photon uncaging experiment. I would be very happy to recommend your MNI glutamate.