MNI-caged-L-Glutamate

(HB0423)

Product overview

  • Name
    MNI-caged-L-Glutamate
  • Short description
    Caged glutamate that rapidly and efficiently releases glutamate when photolysed
  • Biological description

    Caged glutamate that rapidly and efficiently releases glutamate when photolysed (300 - 380 nm excitation).

    Inactive at glutamate receptors and transporters at mM concentrations.

    Water soluble, resistant to hydrolysis and stable at neutral pH.


    Not currently for sale in the USA.

  • Alternative names
    MNI-Glu, Caged glutamate, MNI-Glutamate,
  • Biological action
    Activator
  • Purity
    >98%
  • Customer comments

    We confirmed Hello Bio MNI-caged-glutamate works very well for our two-photon uncaging experiment. I would be very happy to recommend your MNI glutamate. Verified customer

    We are very pleased to have such a company like yours that offers products like MNI-Glu at a very good price and still with a high quality. So we will rate your product 5 stars! Verified customer, LIN, Magdeburg

  • Citations

Images

Properties

  • Chemical name
    (S)-α-Amino-2,3-dihydro-4-methoxy-7-nitro-δ-oxo-1H-indole-1-pentanoic acid
  • Molecular Weight
    323.3
  • Chemical structure
    MNI-glutamate [295325-62-1]
  • Molecular Formula
    C14H17N3O6
  • CAS Number
    295325-62-1
  • PubChem identifier
    6604871
  • SMILES
    COC1=C2CCN(C2=C(C=C1)[N+](=O)[O-])C(=O)CC[C@@H](C(=O)O)N
  • Source
    Synthetic
  • InChi
    1S/C14H17N3O6/c1-23-11-4-3-10(17(21)22)13-8(11)6-7-16(13)12(18)5-2-9(15)14(19)20/h3-4,9H,2,5-7,15H2,1H3,(H,19,20)/t9-/m0/s1
  • InChiKey
    GXIDBZKXGUNITQ-VIFPVBQESA-N
  • Appearance
    Yellow solid

Storing and Using Your Product

  • Storage instructions
    -20 °C
  • Solubility overview
    Soluble in water (50mM) with gentle warming
  • Handling
    This compound is light sensitive; exposure to light may affect compound performance. We therefore recommend storing the material in the dark and protecting from light.
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for MNI-caged-L-Glutamate

  • Photochemical and pharmacological evaluation of 7-nitroindolinyl-and 4-methoxy-7-nitroindolinyl-amino acids as novel, fast caged neurotransmitters.

    Canepari et al (2001) J Neurosci Methods 112(1) : 29-42
    PubMedID: 11640955
  • Comparative analysis of inhibitory effects of caged ligands for the NMDA receptor.

    Maier et al (2005) J Neurosci Methods 142(1) : 1-9
    PubMedID: 15652611
  • New caged neurotransmitter analogs selective for glutamate receptor sub-types based on methoxynitroindoline and nitrophenylethoxycarbonyl caging groups.

    Palma-Cerda et al (2012) Neuropharmacology 63(4) : 624-34
    PubMedID: 22609535

Reviews

  • Verified customer, LIN Magdeburg

    We are very happy with the quality and price of the MNI-caged-L-glutamate (MNI-Glu) from Hello Bio.
    We are currently using the compound to study dendritic integration, by uncaging MNI-Glu on multiple dendritic spines of hippocampal cells in acute brain slices. We are very excited about the potential results.
    Experiments using MNI-Glu are more often very expensive, especially if one chooses to apply the compound in the bath in order to have a more stable and homogenous concentration. We are very pleased to have such a company like yours that offers products like MNI-caged-L-glutamate at a very good price and still with a high quality.
    So we will rate your product 5 stars!
  • Verified customer

    We confirmed Hello Bio MNI-caged-L-glutamate (MNI-glu) works very well for our two-photon uncaging experiment. I would be very happy to recommend your MNI glutamate.