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NBQX disodium salt


Product overview

  • Name
    NBQX disodium salt
  • Short description
    Potent, selective, competitive AMPA receptor antagonist. Disodium salt.
  • Biological description

    Potent, selective and competitive AMPA receptor antagonist. Also kainate receptor antagonist. Water soluble, disodium salt. Shows neuroprotective, antinociceptive and anticonvulsive actions. NBQX also available.

  • Biological action
  • Purity
  • Customer comments

    High quality and affordable! We use this compound routinely in the lab for neuronal recordings. Verified customer, The University of Montana

    Worked just as it should, results indistinguishable from our previous product but at a significant cost reduction! Verified customer, The University of Toronto

    Good quality and great price! Verified customer, The University of Newcastle

    NBQX disodium salt produced by Hello Bio produced a very potent and "clean" block of synaptic AMPA currents, with no effect on other GABAA or NMDA receptors.Verified customer, The University of Edinburgh

  • Citations



  • Chemical name
    2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide disodium salt
  • Molecular Weight
  • Chemical structure
    NBQX disodium salt  [479347-86-9]
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • Source
  • InChi
  • InChiKey
  • MDL number
  • Appearance
    Orange solid


  • Application notes

    The AMPA receptor antagonist NBQX disodium salt inhibits the actions of glutamate by acting at AMPARs and is commonly used at 10 μM. NBQX disodium salt from Hello Bio inhibits spontaneous and evoked excitatory post synaptic currents (EPSCs) (see Fig 1 above). Complete AMPA receptor blockade was achieved at 10 μM and NBQX disodium salt was also effective at reducing these currents at 1 μM. 


    #Protocol 1: Evoked and spontaneous excitatory post synaptic currents (EPSCs)

    • Whole cell voltage clamp recordings were obtained from layer V neurons of the mouse prelimbic cortex brain slice.
    •  EPSCs were evoked via a stimulating electrode placed in layers II/III delivering a single square (150 μs) pulse every 10 sec at an intensity that gave a reliable EPSC.
    • Neurons were held at -70 to -60 mV (the reversal potential of GABA currents). EPSCs were continuously stimulated and recorded in response to 5 min applications of varying concentrations of NBQX disodium salt until complete receptor inhibition.
    • Spontaneous EPSCs were recorded before and after addition of NBQX disodium salt by holding the neuron at -70 mV and recording for 10 sec.
    • Recordings for EPSCs were made in the absence of GABAA-R antagonists.

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    Soluble in water (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for NBQX disodium salt

  • It is AMPA receptor, not kainate receptor, that contributes to the NBQX-induced antinociception in the spinal cord of rats.

    Kong LL et al (2006) Brain Res 1100(1) : 73-7.
    PubMedID: 16777075
  • Competitive inhibition by NBQX of kainate/AMPA receptor currents and excitatory synaptic potentials: importance of 6-nitro substitution.

    Randle JC et al (1992) Eur J Pharmacol 215(2-3) : 237-44.
    PubMedID: 1382998
  • Both MK801 and NBQX reduce the neuronal damage after impact-acceleration brain injury.

    Goda M et al (2002) J Neurotrauma 19(11) : 1445-56.
    PubMedID: 12490009
  • Antiepileptogenic and anticonvulsant effects of NBQX, a selective AMPA receptor antagonist, in the rat kindling model of epilepsy.

    Namba T et al (1994) Brain Res 638(1-2) : 36-44.
    PubMedID: 8199874
  • Pharmacological characterization of glutamatergic agonists and antagonists at recombinant human homomeric and heteromeric kainate receptors in vitro.

    Alt et al (2004) Neuropharmacology 46(6) : 793-806
    PubMedID: 15033339
Our products in action
The following papers have cited the use of NBQX disodium salt (HB0443) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • mGluR-LTD at Excitatory and Inhibitory Synapses in the Lateral Habenula Tunes Neuronal Output.

    Valentinova and Mameli( 2016) Cell Rep 16(9) : 2298-307
    PubMedID: 27545888
  • PAR1 activation induces rapid changes in glutamate uptake and astrocyte morphology.

    Sweeny et al (2017) Sci Rep. 7 : 43606
    PubMedID: 28256580
  • Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms.

    Tchenio et al(2017) Nat Commun 8(1) : 1135
    PubMedID: 29074844
  • Neuronal glutamate transporters control dopaminergic signaling and compulsive behaviors

    Bellini et al(2017) bioRxiv :
  • A Caged Enkephalin Optimized for Simultaneously Probing Mu and Delta Opioid Receptors.

    Banghart et al(2017) ACS Chem Neurosci doi: 10.1021/acschemneuro.7b00485 : [Epub ahead of print]
    PubMedID: 29266926
  • Positive regulation of raphe serotonin neurons by serotonin 2B receptors.

    Belmer et al (2018) Neuropsychopharmacology doi: 10.1038/s41386-018-0013-0. : [Epub ahead of print]
    PubMedID: 29453444
  • Investigating the role of fast-spiking interneurons in neocortical dynamics

    Papasavvas (2018) Newcastle University : Thesis
  • Enhanced Postsynaptic GABAB Receptor Signaling in Adult Spinal Projection Neurons after Neonatal Injury.

    Baccei and Brewer (2018) Neuroscience 384 : 329-339
    PubMedID: 29885525
  • Co-transmission of acetylcholine and GABA regulates hippocampal states.

    Takacs et al(2018) Nat Commun 9(1) : 2848
    PubMedID: 30030438
  • Vascular Compartmentalization of Functional Hyperemia from the Synapse to the Pia.

    Rungta et al(2018) Neuron 99(2) : 362-375
    PubMedID: 29937277
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Support & Resources


  • Verified customer

    Great compound! We use NBQX in our external recordings solutions for slice electrophysiology to block AMPA receptors. This is a great water soluble option for NBQX.
  • Verified customer

    Reasonable price and it works as it should.
  • Verified customer, UC Denver

    Good product, great price. Works as it should.
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