Product overview

  • Name
    (R)-CPP
  • Short description
    Potent NMDA receptor antagonist
  • Biological description
    Potent NMDA receptor antagonist. Selective for GluN2A subtypes over GluN2B, GluN2C and GluN2D subtypes (Ki values are 41 nM, 0.27, 0.63 and 1.99 μM respectively). Blocks LTP induction, induces glutamate release and causes attention deficits in rats.
  • Biological action
    Antagonist
  • Our products in action

Properties

  • Chemical name
    3-((R)-2-Carboxypiperazin-4-yl)-propyl-1-phosphonic acid
  • Molecular Weight
    252.21
  • Chemical structure
    (R)-CPP  [126453-07-4]
  • Molecular Formula
    C8H17N2O5P
  • CAS Number
    126453-07-4
  • PubChem identifier
    6603754
  • SMILES
    C1CN(C[C@@H](N1)C(=O)O)CCCP(=O)(O)O
  • InChi
    InChI=1S/C8H17N2O5P/c11-8(12)7-6-10(4-2-9-7)3-1-5-16(13,14)15/h7,9H,1-6H2,(H,11,12)(H2,13,14,15)/t7-/m1/s1
  • InChiKey
    CUVGUPIVTLGRGI-SSDOTTSWSA-N
  • Formulation
    White solid

Storing and Using Your Product

  • Storage instructions
    Room temperature (desiccate)
  • Solubility overview
    Soluble in water (100mM)

References for (R)-CPP

  • Structure-activity analysis of a novel NR2C/NR2D-preferring NMDA receptor antagonist: 1-(phenanthrene-2-carbonyl) piperazine-2,3-dicarboxylic acid.

    Feng B et al (2004) Br J Pharmacol 141(3) : 508-16.
    PubMedID: 14718249
  • Long-term potentiation promotes proliferation/survival and neuronal differentiation of neural stem/progenitor cells.

    Cho T et al (2013) PLoS One 8(10) : e76860.
    PubMedID: 24146937
  • Sertindole restores attentional performance and suppresses glutamate release induced by the NMDA receptor antagonist CPP.

    Carli M et al (2011) Psychopharmacology (Berl) 214(3) : 625-37.
    PubMedID: 21049266