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Salvinorin B (SALB)


Product overview

  • Name
    Salvinorin B (SALB)
  • Short description
    Potent, selective KORD DREADD activator
  • Biological description

    Salvinorin B (SALB) is a pharmacologically inert ligand that potently and selectively activates the KORD (the κ-opioid designer receptor (DREADD)) (EC50 = 11.8 nM).

    Salvinorin B (SALB) is ~100-fold selective for the KORD DREADD over human κ opioid receptor and other targets and shows good CNS penetrability.

    Activation of KORD by Salvinorin B (SALB) induces neuronal inhibition and modifies behaviour in vivo.

    Salvinorin B (SALB) can be used in mice also expressing Clozapine N-Oxide (CNO) responsive DREADDS, to allow bi-directional manipulation of neural circuits.

    CNO dihydrochloride (water soluble), Clozapine N-oxide (CNO) freebase, Compound 21 and perlapine freebase also available.

  • Alternative names
    SALB, Divinorin B
  • Biological action
  • Purity
  • Citations


  • Chemical name
    (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(3-Furanyl)dodecahydro-9-hydroxy-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester
  • Molecular Weight
  • Chemical structure
    Salvinorin B | [92545-30-7]
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • Source
    Extracted from salvia divinorum
  • InChi
  • InChiKey
  • MDL number
  • Appearance
    Off-white solid

Storing and Using Your Product

  • Storage instructions
    -20 °C
  • Solubility overview
    Soluble in DMSO (20 mM)
  • Handling

    • This compound is light sensitive; we therefore recommend protecting the solid and solutions from exposure to light.
    • Salvinorin B (SalB) is unstable in solution and we recommend that solutions are stored at -20°C and used within 24 hours.

  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Salvinorin B (SALB)

  • A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior.

    Vardy et al (2015) Neuron. 86(4) : 936-46.
    PubMedID: 25937170
  • DREADDS: Use and application in behavioral neuroscience.

    Smith et al (206) Behav Neurosci 130(2) : 137-55.
    PubMedID: 26913540
  • Behavioral and Physiological Effects of a Novel Kappa-Opioid Receptor-Based DREADD in Rats.

    Marchant et al (2016) Neuropsychopharmacology 41(2) : 402-9.
    PubMedID: 26019014
  • Antinociceptive and hypothermic effects of Salvinorin A are abolished in a novel strain of kappa-opioid receptor-1 knockout mice.

    Ansonoff MA et al (2006) J Pharmacol Exp Ther 318 (2): : 641-8.
    PubMedID: 16672569
Support & Resources


  • Verified customer, Stony Brook University

    High quality with better price. I have compared SalB (Salvinorin B)) from different producer, Hello Bio really provide a high quality compound with a cheaper price. Would definitely order again from here.