Ionomycin calcium salt
Calcium ionophore. Stimulates cytokine production.
Ionomycin calcium salt is a potent calcium ionophore which shows selectivity for Ca2+ over Mg2+ and K+. It acts as a Ca2+ carrier and is the calcium salt of ionomycin.
Ionomycin directly stimulates store-regulated cation entry across biological membranes to enhance Ca2+ influx and increase intracellular Ca2+ concentration.
Ionomycin also synergies with phorbol myristate acetate (PMA) to enhance activation of PKC and is frequently used in combination with PMA to stimulate T-cell activation and intracellular production of cytokines.
Ionomycin also induces apoptosis.
Calcium ionophore A23187 also available.
Ionomycin calcium salt does what it should. This was my first time buying a product from Hello Bio. I am pleased with their customer service and follow up. The product was delivered in a relatively short time as estimated. The product dose causes the intracellular calcium to be released as expected. Overall experience with Hello Bio was good. Verified customer, UEA: University of East Anglia)
(4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-10,16-docosadienoic acid calcium salt
White to off-white
Storing and Using Your Product
Soluble in ethanol (100 mM) and DMSO (25 mM)
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Ionomycin calcium salt
Characterization of ionomycin as a calcium ionophore.Liu C et al (1978) J Biol Chem 253(17) : 5892-4.PubMedID: 28319
Cation transport and specificity of ionomycin. Comparison with ionophore A23187 in rat liver mitochondria.Kauffman RF et al (1980) J Biol Chem 255(7) : 2735-9.PubMedID: 6766939
PMA and ionomycin induce glioblastoma cell death: activation-induced cell-death-like phenomena occur in glioma cells.Han S et al (2013) PLoS One 8(10) : e76717.PubMedID: 24130787
Reviews & Product Guides
Ionomycin calcium salt does what it should. This was my first time buying a product from Hello Bio. I am pleased with their customer service and follow up. The product was delivered in a relatively short time as estimated. The product dose causes the intracellular calcium to be released as expected. Overall experience with Hello Bio was good.