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Perlapine dihydrochloride (water soluble)


Product overview

  • Name
    Perlapine dihydrochloride (water soluble)
  • Short description
    Perlapine has been indicated to be a novel, potent and selective hM3Dq DREADD receptor agonist. Water soluble.
  • Biological description

    Perlapine dihydrochloride is a water soluble version of perlapine which has been indicated to be a novel, potent and selective hM3Dq DREADD receptor agonist (EC50 = 2.8 nM). Perlapine also activates the inhibitory hM2Di and hM4Di Gi-DREADDs.

    Perlapine shows >10,000-fold selectivity for hM3Dq over hM3 muscarinic receptor.

    Unlike CNO, perlapine is especially suited for translational studies. Perlapine also acts as a sleep inducing, hypnotic agent.

    CNO dihydrochloride (water soluble), Clozapine N-oxide (CNO) freebase, Compound 21, Salvinorin B (SalB) and perlapine freebase also available.

  • Alternative names
    NSC291840 dihydrochloride
  • Biological action
  • Purity
  • Citations


  • Chemical name
    6-(4-Methyl-1-piperazinyl)-11H-dibenz[b,e]azepine dihydrochloride
  • Molecular Weight
  • Chemical structure
    Perlapine hydrochloride
  • Molecular Formula
  • Source
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    Soluble in water (100 mM). Always store solutions at -20°C.
  • Handling

    • Hydroscopic solid, contact with air may cause material to become sticky. Product performance should not be affected but we recommend storing the material in a sealed jar.
    • Always store solutions at -20°C.

  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

References for Perlapine dihydrochloride (water soluble)

  • The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs.

    Chen et al (2015) ACS Chem Neurosci 6(3) : 476-84
    PubMedID: 25587888
  • 6-(4-Methyl-1-piperazinyl)morphanthridine (Perlapine), a new tricyclic compound with sedative and sleep-promoting properties. A pharmacological study.

    Stille et al (1973) Psychopharmacologia 24(4) : 325-37
    PubMedID: 4695567
  • DREADDs for Neuroscientists.

    Roth Bl (2016) Neuron 89(4) : 683-94
    PubMedID: 26889809
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